Haemophilis influenzae

Smith et al., reported restriction endonuclease from Haemophilis influenzae that recognizes specific DNA target sequences. 

Kurono, Y., Yamamoto, M., Fujihashi, K., Kodama, S., Suzuki, M., Mogi, G., McGhee, J. R., and Kiyono, H. (1991), Nasal immunization induces Haemophilis influenzae-specific Thl and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity,/. Infect. Dis., 180,122-132. 

Lomefloxacin, a fluoroquinolone broad-spectrum antibiotic (400 mg p.o. daily for 10 to 14 days), is used in acute bacterial exacerbations of chronic bronchitis caused by Haemophilis influenzae or Moraxella (Branhamella) catarrhalis in uncomphcated urinary tract infections (cystitis) caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Staphylococcus saprophyticus, in complicated urinary tract infections caused by E. coli, K. pneumoniae, P. mirabilis, and Pseudomonas aeruginosa and it is possibly effective against infections caused by Citrobacter diversus or Enterobacter cloacae and for the prophylaxis of infections after transurethral surgical procedures (see also Figure 85). 

Sterility is the most important requirement concerning ophthalmic preparations. A diseased or injured eye is extremely sensitive to infections with catastrophic consequences. Pseudomonas aeruginosa is the most feared organism due to the organism causing serious and difficult to treat corneal ulceration, which can result in rapid loss of vision. Other bacteria such as Bacillus subtilis. Staphylococcus aureus and Haemophilis influenzae as well as yeasts and moulds such as Aspergillus fumigatus, Fusarium species and Candida albicans (or non-albicans) are responsible for serious eye infections. 

Haemophilis influenzae (type b and nontypeable) <5% Nosocomial outbreaks reported in pediatric and elderly patients... 

Clarithromydn (Fig. 8.18) was spedfically designed to be more stable in add by converting the alcohol at the 6 position to an ether, thus preventing carbonium ion formation. The enhanced oral bioavailability is reflected in a halving of the typical dose when compared to erythromydn. It also turned out serendipitously to have improved activity against Haemophilis influenzae. 

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