Haematological values

Wepener, V., J.H.J. van Vuren, and H.H. Du Preez. 1992. The effect of hexavalent chromium at different pH values on the haematology of Tilapia sparrmanii (Cichlidae). Comp. Biochem. Physiol. 101C 375-381. 

Ellegaard, L., Jorgensen, K.D., Klastbruck, S., Hansen, A.K. and Svendsen, O. (1995). Haematologic and clinical chemical values in three- and six-month old Gottinger minipigs. Scand J. Lab Anim. Sci. 22 239-248. 

Matsuzawa, T., H. Tabata, M. Sakazume, S. Yoshida, and S. Nakamura. 1994. A comparison of the effect of bleeding site on hematological and plasma chemistry values of F344 rats The inferior vena cava, abdominal aorta, and orbital venous plexus. Comparative Haematology International 4 207-211. 

Increases are found after myocardial infarction (reaching a peak value 48-72 hours after the event), haematological disorders, and liver and skeletal muscle disease. 

Haematologic Thrombocytopenia has been reported in a 61-year-old Caucasian hypertensive man who had his losartan increased from 50 to 100 mg per day [16 ]. Platelet count dropped from the baseline value of 280 x lO cells/L to 15 X lO cells/L. Following prednisone taper, his platelet count returned to >200 x 10 cells/L and losartan was replaced with valsartan. Forty-seven days after commencement of valsartan, the platelet count dropped again to 37 X lO cells/L. Valsartan was withheld and prednisolone taper recommenced and the platelet count improved to 214 X IPP cells/L. The authors suggested the possibility of antibody cross-reactivity between losartan and valsartan due to similarity in their molecules. 

Halofuginone is of relatively high acute toxicity in rats and mice with oral LD50 values of 30 and 5 mg/kg bw when tested as the lactate or hydrobromide salts. The acute inhalation LC50 was 53 pg L in the rat while the acute dermal LD50 was 16 mg/kg bw in the rabbit. In 4 week toxicity studies in mice the main effects were on haematological parameters with alterations in cell volume, mean cell volume, and mean cell haemoglobin at doses of 0.16 and... 

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