Group A streptococcus

The primary goal of therapy for impetigo is resolution of infection. A secondary goal is prevention of glomerulonephritis (although extremely rare) secondary to group A Streptococcus (GAS). 

Cifonelli The Biosynthesis of Hyaluronic Acid by Group A Streptococcus. IV. Role of Glucosone as an Intermediate in the Synthesis of Glucosamine. J. biol. Chemistry 216, 549 (1955)-... 

Primary bacterial peritonitis is often caused by a single organism. In children, the pathogen is usually Group A Streptococcus, Streptococcus... 

In the pediatric age group, most pneumonias are due to viruses, especially respiratory syncytial virus, parainfluenza, and adenovirus. Pneumococcus is the most common bacterial cause, followed by Group A Streptococcus and S. aureus. 

Nonsuppurative complications such as acute rheumatic fever, acute glomerulonephritis, and reactive arthritis may occur as a result of pharyngitis with Group A Streptococcus. 

Guidelines from the Infectious Disease Society of America, American Academy of Pediatrics, and the American Heart Association suggest that testing for Group A Streptococcus be done in all patients with signs and symptoms. Only those with a positive test for Group A Streptococcus require antibiotic treatment. 

Most cases of pharyngitis are self-limited however, antimicrobial therapy will hasten resolution when given early to proven cases of group A Streptococcus. Symptoms generally resolve by 3 to 4 days even without therapy. Children should be kept home from daycare or school until afebrile and for the first 24 hours after antimicrobial treatment is initiated,... 

Evidence-Based Principles for Diagnosis of Group A Streptococcus... 

Group A Streptococcus—Test Case for a Very Large Receptor. 78... 

DRPVPY mAb SA-3 Group A Streptococcus cell-wall polysaccharide [25]... 

Scheme 4 Structures of the Group A Streptococcus cell-wall polysaccharide, and of branched trisaccharide (1) and hexasaccharide (2) fragments recognized by antibodies...

Fig. 7 A model of the cell-wall polysaccharide (CWPS) of group A Streptococcus, looking down the barrel of the helix. The core of the helix is composed of a-L-rhamnose residnes with the 8-d-G1cNAc moieties displayed on the periphery. Reprodnced with permission from [99]. 2004 Elsevier Science...

E. The patient has exudative pharyngitis, presumably secondary to group A streptococcus. Antibiotic treatment is indicated to reduce the duration and severity of symptoms and to prevent acute rheumatic fever. The antibiotic of first choice is penicillin V. Other reasonable alternatives are benzathine penicillin G, erythromycin, cephalosporin, clindamycin, azithromycin, and clarithromycin. Amikacin, lome-fioxacin, metronidazole, and netilmicin are not active against group A streptococcus. 

Cellulitis S aureus, group A streptococcus Penicillinase-resistant penicillin, cephalosporin (first-generation)2 Vancomycin, clindamycin, linezolid, daptomycin... 

Pathogenic Group A Streptococcus 2003 A IPCR approximately 10 cells Liang et al. [74], covalent antibody-... 

Liang H, Cordova SE, Kieft TL, Rogelj S. A highly sensitive immuno-PCR assay for detecting Group A Streptococcus. J Immunol Methods 2003 279(1-2) 101-110. 

The device has been used to capture DNA sequences in very complex mixtures [45]. For the experiment shown in Fig. 10, a model target sequence consisting of a 75-mer based on a sequence from group A Streptococcus pyogenes (GAS) was synthesized and labeled with the fluorophore Bodipy Texas Red. In addition, the unlabeled complement to the 75-mer was synthesized. Equimolar amounts of the two oligonucleotides in amounts varying from 0.1 to 10 nM were combined with 2 pg sheared and denatured human DNA with a final volume of... 

Dorschner, R.A., Pestonjamasp, V.K., Tamakuwala, S et al. (2001) Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A streptococcus. J. Invest. Dermatol. 117, 91-97. 

Human serum containing anti-group A streptococcus carbohydrate (GAS CHO) antibodies were opsonic for different M protein-carrying serotypes. 

Russell-Jones GJ (2000) Oral vaccine delivery. J Control Release 65(1-2) 49-54 Sabharwal H, Michon F, Nelson D, Dong W, Fuchs K, Manjarrez RC, Sarkar A, Uitz C, Viteri-Jackson A, Suarez RSR, Blake M, Zabriskie JB (2006) Group A Streptococcus (GAS) Carbohydrate as an Immunogen for Protection against GAS Infection. J Infect Dis 193(1) 129-135... 

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