GRASP

In science in general, and in chemistry and in pharmaceutical research in particular, huge amounts of data are produced. The intrinsic information in these data is often difficult to grasp. In many cases, not only are the data themselves interesting, but the intrinsic relationships among the data are of particular interest. 

Breslow immediately grasped the significance of his observation. He interpreted this discovery in terms of a hydrophobic effect Since in the Diels-Alder reaction. .. the transition state. .. brings together two nonpolar groups, one might expect that in water this reaction could be accelerated by hydrophobic interactions ". ... 

The course instructors or professors have not tried to intentionally deceive their students. Most individuals cannot grasp the full depth and detail of any chemical concept the first time that it is presented to them. It has been found that most people learn complex subjects best when first given a basic description of the concepts and then left to develop a more detailed understanding over time. Despite the best elforts of educators, a few misconceptions are at times possibly introduced in the attempt to simplify complex material for freshmen students. The part of this process that perpetuates any confusion is the fact that texts and instructors alike often do not acknowledge the simplifications being presented. 

The relationship of the selectivity of an electrophile to its reactivity is a separate issue, because the above quantitative correlations of reactivity can be used empirically, without accepting that they allow comment about the reactivity of electrophiles. There is no direct evidence for the view that differences in the selectivities of electrophiles are related in a simple way to their different reactivities. Indeed, it is difficult to grasp the meaning of comparisons attempted between electrophiles of very different structures, which bring about reaction under disparate conditions by different mechanisms. 

Once we grasp the idea of stereoisomerism m molecules with two or more chirality cen ters we can explore further details of addition reactions of alkenes... 

Vertical rotary molds also employ multiple molds on a turret but rotate in a vertical plane. As each mold reaches the die exit, it grasps the parison and closes. Because of the vertical spacing between molds, intermittent extmder action is not required. Vertical wheels are used commercially for high volume apphcations. 

The fusion name l//-triazolo[4,5-d]pyrimidine for (140) is preferred by practitioners in the field and appears in CA indexes. On the other hand, the nonspecialist, who may well be uncertain about his command of fusion nomenclature, might more easily grasp the replacement name l//-l,2,3,4,6-pentaazaindene. (This is an appropriate place to emphasize that, by lUPAC rules, replacement names are to be based only on a completely carbocyclic parent. Notwithstanding the attractive simplicity of 8-azapurine for the example at hand, it has no sanction see, however. Section 1.02.3.2. The purpose of this avoidance is to forestall a multiplicity of names for systems containing several hetero atoms.)... 

Conclusions from the test problems are not limited by any means to methanol synthesis. These results have more general meaning. Other reactions also will be used to explain certain features of the subjects. Yet the programs for the test problem make it possible to simulate experiments on a computer. In turn, computer simulation of experiments by the reader makes the understanding of the experimental concepts in this book more profound and at the same time easier to grasp. 

The equation of motion as given in terms of angular momentum can be transformed into other forms that are more convenient to understanding some of the basic design components. To understand the flow in a turbomachine, the concepts of aboslute and relative velocity must be grasped. Absolute velocity (V) is gas velocity with respect to a stationary coordinate system. Relative velocity (IV) is the velocity relative to the rotor. In turbomachinery. 

Because carbocations are key intermediates in many nucleophilic substitution reactions, it is important to develop a grasp of their structural properties and the effect substituents have on stability. The critical step in the ionization mechanism of nucleophilic substitution is the generation of the tricoordinate carbocation intermediate. For this mechanism to operate, it is essential that this species not be prohibitively high in energy. Carbocations are inherently high-energy species. The ionization of r-butyl chloride is endothermic by 153kcal/mol in the gas phase. ... 

Tasks that once were simple, such as bending over or grasping implements, were greatly impeded. Although some tasks could still be performed, the rate at which they were performed was substantially reduced. 

To fully grasp the main feature of the gas-liquid precipitation phenomena, however, it is not enough just to account for the formation of crystal particles, evaluation of the Hatta number is also essential. 

Many operators find it hard to grasp the power of compressed air. Section 2.2 (a) describes how the end was blown off a pressure vessel, killing two men, because the vent was choked. Compressed air was being blown into the vessel, to prove that the inlet line was clear. It was estimated that the gauge pressure reached 20 psi (1.3 bar) when the burst occurred. The operators found it hard to believe that a pressure of only twenty pounds could do so much damage. Explosion experts had to be brought in to convince them that a chemical explosion had not occurred. 

---