Granulocytes, progenitors

Granulocyte colony-stimulating factors G-CSF, an 18 kDa protein encoded by a gene on the long arm of chromosome 17 (17q), stimulates the proliferation of granulocyte progenitors and activates neutrophil function. 

White Blood Cells. White blood cells, or leukocytes, have varying function and morphology. Mononuclear leukocytes include lymphocyte B and T-ceUs, monocytes, and progenitor cells. Polynuclear granulocytes include neutrophils, basophils, and eosinophils. The most important groups in cell separation are lymphocytes, monocytes, and granulocytes. 

Sato N, Sawada K, Takahashi TA, et al. A time course study for optimal harvest of peripheral blood progenitor cells by granulocyte colony-stimulating factor in healthy volunteers. Exp Hematol 1994 22 973-978. 

Broxmeyer HE, Sherry B, Lu L, et al. Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells. J Exp Med... 

Thomas J, Liu F, Link DC. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol 2002 9(3) 183-189. 

IL-6 (21-28) Monocyte/macrophage, T cell endothelium, fibroblast, keratinocyte Induction of fever and the hepatic acute phase response. Stimulates cortisol production. Decreases IL-1 and TNF production. Participates in activation of B and T cells, facilitates Ig production by B cells. Induction of granulocyte-macrophage colony-stimulating factor, stimulation of hematopoietic progenitors. 

Main target cells Neutrophils. Also other haemopoietic progenitors and endothelial cells Macrophages and their precursor cells Haematopoietic progenitor cells Granulocytes Monocytes Endothelial cells Megakaryocytes T-lymphocytes Erythroid cells... 

Proliferation/differentiation factor of haemopoietic progenitor cells, particularly those yielding neutrophils (a variety of granulocyte) and macrophages, but also eosinophils, erythrocytes and megakarycytes. In vivo studies also demonstrate this cytokine s ability to promote haemopoiesis. 

The first site of myelopoiesis75 in the mouse embryo is the fetal liver, where the common myeloid progenitor, the megakaryocyte-erythrocyte-restricted progenitors and granulocyte-monocyte restricted progenitors are present. Myelopoiesis occurs in the fetal liver in the same manner as in adult bone marrow.81 However, the proliferation capacity, colony forming activity and differentiation capacity is different between the fetal liver and adult bone marrow.81... 

Granulocytes and macrophages Macrophages and granulocytes Granulocytes, macrophages, eosinophils, mast cells, and pluripotent progenitor cells... 

Higuchi, M., O Brien, D., Lenny, N., Yang, S., Cai, Z. and Downing, J. (2000) Expression of AMLl-ETO immortalizes myleloid progenitors and cooperates with secondary mutations to induce granulocytic sarcoma / acute myeloid leukemia. Blood 1, 63-74. 

Pessina, A., Croera, C., Bayo, M., Malerba, L, Passardi, L, Cavicchini, L., Neri, M.G. and Gribaldo, L. (2004) A methylcellulose microculture assay for the in vitro assessment of drug toxicity on granulocyte/macrophage progenitors (CFU-GM). Alternatives to Laboratory Animals, 32, 17-23. 

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