Granulation wetting

In general, the manufacturing process used for the majority of these tablets are the same as those used for humans and are discussed elsewhere (chap. 13, vol. 1). Direct compression and granulation (wet, dry) are both used. Chewable tablets can also be made by these methods or sometimes are molded via excursion and cut into appropriate sizes. The terms chewable tablets and treats are sometimes confusing. One way to classify is to state that chewable tablets that are made by direct or granulation processes are then called tablets. This would be similar to the mannitol-based chewable tablets prevalent for humans. The term treat is used for the more soft tablets that are produced via extrusion or cast molding. 

In this chapter the different types of interparticle forces and their relative importance as a function of particle size are summarized. Liquid bridge forces, which are specifically important to granulation processes, are covered in more detail. The rate processes important to granulation (wetting, growth, consolidation... 

Attrition Oscillating granulator Coarse to moderate Dried granulation Wet granulation, abrasive materials... 

The effect of formulation variables, such as granule wetness (binder volume), drying temperature and compression pressure, and the swelling capacity (index) of... 

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