Process-Induced Form Changes in Wet Granulation

Studying such phase transformations by conventional techniques (e.g., X-ray powder diffraction) may not be feasible for potent dmgs that are present in the formulation at low levels. Other methods may be more appropriate for such cases, like solid-state NMR techniques.57 The different analytical techniques used to study potential phase transformations will not be discussed here, because this is the focus of another chapter in this book. 

The kinetics of the possible phase changes are important in determining whether such changes will be complete during the manufacturing process, or on storage.55 The extent of conversion will depend on the amount of dmg substance dissolved during 

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