DEVELOPMENT OF LOW-DOSE SOLID ORAL FORMULATIONS USING WET GRANULATION

DEVELOPMENT OF LOW-DOSE SOLID ORAL FORMULATIONS USING WET GRANULATION 

Pharmaceutical Sciences R D, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 

There are different reasons for granulation, the most important of which are the following 1 1 

Formulation and Analytical Development for Low-Dose Oral Drug Products. Edited by Jack Zheng Copyright 2009 John Wiley Sons, Inc. 

This may lead to larger weight variation on a tablet press, or to a poor content uniformity within individual dosage units if the active ingredient is not distributed uniformly in small and large granules. 

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