Gonadotropin-releasing hormone analogues

Paoletti AM, Serra GG, Cagnacci A, Vacca AM, Guerriero S, Solla E, Melis GB. Spontaneous reversibility of bone loss induced by gonadotropin-releasing hormone analogue treatment. Fertil Steril 1996 65(4) 707-10. 

Pierce SJ, Gazvani MR, Farquharson RG. Long-term use of gonadotropin-releasing hormone analogues and hormone replacement therapy in the management of endometriosis a randomized trial with a 6-year follow-up. Fertil Steril 2000 74(5) 964-8. 

Gonadotropin Releasing Hormone Analogues (leuprorelin, buserelin, triptorelin, goserelin)... 

Moghissi KS. A cUnician s guide to the use of gonadotropin-releasing hormone analogues in women. Medscape Womens Health 2000 5 5. 

Induced ovulation of sonthem flounder Paralichthys lethostigma using gonadotropin releasing hormone analogue implants ,/onma/ of World Aquaculture Society, vol. 27, pp. 143-152. 

Casper, R.F. (1991) Chnical uses of gonadotropin-releasing hormone analogues. Canadian Medical Association Journal, 144,153-158. 

Okada, H., et al. 1983. Vaginal absorption of a potent luteinizing hormone-releasing hormone analogue (leuprolide) in rats. IV. Evaluation of vaginal absorption and gonadotropin responses by radioimmunoassay. J Pharm Sci 73 289. 

H. Meirovitch, S. C. Koerber, J. Riviec, and A. T. Hagler, Biopolymers, 34,815 (1994). Computer Simulation of the Free Energy of Peptides with the Local States Method Analogues of Gonadotropin Releasing Hormone in the Random Coil and Stable States. 

Miller, L., Kolaskie, C, Smith, G., and Rivier, J., 1990, Transdermal iontophoresis of gonadotropin releasing hormone (LHRH) and two analogues, J. Pharm. Sci 79 490-493. 

Example of bioactive peptide synthesis under kinetic control using a-chymotrypsin in water-cosolvent medium [5]. The gonadotropin-releasing hormone (PCA-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NHj) analogue [D-Phe ]GnRH was obtained in 97.5% yield. Abbreviations PCA, pyroglutamic acid. 

Buserelin (Suprefact) and leuprolide (Lupron) are peptide analogues of the hypothalamic hormone LH-RH (luteinizing hormone-releasing hormone). Chronic exposure of the pituitary to these agents abolishes gonadotropin release and results in markedly decreased estrogen and testosterone production by the gonads. Their major clinical use is in the palliative hormonal therapy of cancer of the prostate. 

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