Gold in tissues

The recognition of metaUic gold in tissue sections, H. E. Harding, J. Clin. Path., 1953, 6, 149. 

Immunocytochemical staining with antibody-gold probes is a powerful way to detect, localize, and quantify antigen molecules in tissue sections and cells (Figure 24.3). Metabolic processes can be followed, epitope mapping of the structural characteristics of macromolecules can be... 

Roberts, W. J. (1935) A new procedure for the detection of gold in animal tissues Physical development. Proc. R. Acad. Sci. Amsterdam 38, 540-544. 

Danscher, G. (1981) Localization of gold in biological tissue. A photochemical method for light and electron microscopy. Histochemistry 71, 81-88. 

Roth, J. (1984) The protein A-gold technique for antigen localization in tissue sections by light and electron microscopy, in Immunolabelling for Electron Microscopy (Polak, J. M. and Vamdell, I. M., eds.), Elsevier, New York, pp. 113-122. 

Adverse effects resulting from gold-accumulation in tissues can include lesions of the mucous membranes, skin eruptions varying from erythema to severe exfoliative dermatitis, proteinuria and nephrosis. A serious hematologic reaction is aplastic anemia. A rather high incidence of gastrointestinal disturbances is seen in patients on auranofin. 

Danscher (1981) 7 Silver probe for gold detection in tissue sections... 

Silver probe for gold detection in tissue sections. 

When Drasch and colleagues (1987) determined the concentration of sulfur mustard in tissues of a deceased victim, they had to employ a combination of dichloro-methane extraction, a thin layer chromatography cleanup on silica plates, followed by derivatization with gold chloride. 

Lenticular chrysiasis appears as fine, dust-like, yellowish, glistening deposits in the anterior capsule or in the anterior suture lines (Figure 35-6).There is no significant correlation between corneal chrysiasis and lenticular chrysiasis, and deposits of gold in either tissue do not cause symptoms. 

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