GnRH

B. H. Vickery and B. Luneneld, GnRH Analogs in Cancer and Human Reproduction, Kluwer Academic, Lancaster, UK, 1989. 

Figure 1 A schematic diagram of the endocrine system of fish. TRH = thyrotrophin releasing hormone GnRH = gonadotrophin releasing hormone CRH = corticotrophin releasing hormone TSH = thyroid stimulating hormone GtH = gonadotrophins I and II ...

Protein Trafficking and Quality Control Gonadotropin-releasing Factor/Hormone (GnRH)... 

Hypogonadotropic hypogonadism Gonadotropin-releasing hormone (GnRH) receptor GnRH peptidomimetic antagonist... 

Kesler, D. J., Cruz, L. C., McKenzie, J. A., and Henderson, E. A., The effect of GNRH burst release on the efficacy of GnRH microcapsules, Proc. Int. Control. Rel. Bioact. Mater.,... 

The ontogenesis of the AOS then, is closely bound up with the formation of its principal connection site within the mature brain. The sequence of events in mammals is revealed as a process which involves (1) early specialisation of presumptive GnRH cells (2) their attachment to and movement along specific (and transient) axonal bundles of the VN and N. terminalis tracts, and (3) coalescence of the neurocrine cells in the hypothalamus, where they complete differentiation as multi-axonal neurocrine cells. 

Fig. 4.6(b) GnRH +ve neurones (relative density) in the brain dot = mammalian, circle = avian, forms. Parasagittal view of distribution in Musk Shrew (Suncus murinus) — from bulb to median eminence (ME), optic X (OC), cerebral aqueduct (Aq), and preoptic area (POA) (from Schwanzel-Fukuda and Pfaff, 1994). 

As with any nervous system, the way in which the AOS functions is regulated by developmental and heritable factors (Chaps. 4 and 6), whose interplay determines its operation under any given conditions. Some of its processes can vary with the prior experience of the individual others are almost invariant and appear as stereotypical responses with little experiential influence. They range from the transient guidance role in GnRH-cell migration, to the alteration in the timing of puberty and the diminution of fertility in adults. Differences in the... 

Bakker J. and Baum M. (2000). Neuroendocrine regulation of GnRH release in induced ovulators. Front Neuroendocrinol 21, 220—262. 

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