GnRH Analogs with Agonist Activity

Gonadorelin, a LHRH (100 meg SC), is used in the diagnosis of hypogonadism (see Table 15). 

GnRH is a decapeptide with the following structure pyro Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (see Table 15). 

GnRH is used to induce puberty in males with idiopathic hypogonadotropic hypogonadism (IHH). GnRH (15 to 150 ng/kg/hour) is administered by an infusion pump that 

GnRH is nsed in females to treat hypothalamic amenorrhea. A deficit in the synthesis of GnRH has been implicated as the source of menstrual disturbances, hypoprolactinemia, anorexia nervosa, stress- and weight-loss-associated amenorrhea, athletes amenorrhea, some forms of the polycystic ovarian disease syndrome, and infertility associated with hypothalamic tumors (see Table 15). 

Ceftriaxone 250 mg IM once or ciprofloxacin 500 mg p.o. once or norfloxacin 800 mg p.o. or cefuroxime axetil 1 g p.o. once plus probenecid 1 g or cefotaxime 1 g IM once or ceftizoxime 500 mg IM once plus Doxycycline 100 mg two times daily for 7 days or tetracycline 500 mg four times daily for 7 days 

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