Gonadotrophin releasing hormone GnRH

GnRH is also used (in both human and veterinary medicine) to improve conception rates by enhancing basal hypothalamic-pituitary function. The preparations utilized clinically are manufactured by direct chemical synthesis and are usually administered by s.c. injection or, sometimes, by i.v. injection. Occasionally it has also been administered intranasally. Frequent injection is often required, particularly if administration is via the i.v. route, as the peptide s plasma half-life is of the order of a few minutes (it is hydrolysed in the plasma and excreted in the urine). 

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McDonnell S Diehl N., Garcia M. and Kenney R. (1989). Gonadotrophin releasing hormone (GnRH) affects precopulatory behavior in testosterone-treated geldings. Physiol Behav 45, 145-149. 

The synthesis and release of both FSH and LH from the pituitary is stimulated by a hypothalmic peptide, gonadotrophin-releasing hormone (GnRH, also known as gonadorelin, luteinizing hormone-releasing hormone (LHRH), or LH/FSH-releasing factor). 

It is potent analogue (200 times more potent) of gonadotrophin releasing hormones (GnRH). 

Fig. 2. Gonadotrophin releasing hormone (GnRH) released in pulses by the hypothalamus stimulates pituitary production and secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH). The hypothalamic-pituitary—gonadal (H-P-G) axis is affected by a variety of external hormones and external factors.

Ferro, V.A., Khan, M.A., McAdam, D et al. (2004) Efficacy of an anti-fertility vaccine based on mammalian gonadotrophin releasing hormone (GnRH-I)—a histological comparison in male animals. Vet. Immunol. Immunopathol. 101(1-2), 73-86. 

Hormones and analogues growth hormone corticotrophin (ACTH) calcitonin desmopressin (DD AVP) lypressin oxytocin buserelin nafarelin progesterone norethisterone 17/1-estradiol testosterone insulin Gonadorelin (Gonadotrophin-releasing hormone GnRH LH-RH)... 

Q4 Hypothalamic hormones control the menstrual cycle via negative feedback loops. The hypothalamus produces gonadotrophin releasing hormone (GnRH), which stimulates secretion of the gonadotrophins FSH and LH from the anterior pituitary gland. 

The episodic secretion of the hypothalamic hormone, gonadotrophin-releasing hormone (GnRH), stimulates synthesis and release of the gonadotrophins. LH (luteinizing hormone) and FSH (follicle-stimulating hormone), from the anterior pituitary. Despite the names, both gontidotrophins act cooperatively on the ovaries in the woman and the testes in the man to stimulate sex hormone secretion and reproductive processes. 

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