Glycoproteins sulfated

Fig. 2. Generalized structure of N-linked oligosaccharide of the pituitary glycoprotein hormones. SO = sulfate, GIcNAc = N — acetylglucosamine, GalNAc = N — acetylgalactosamine, Man = mannose, Fuc = fucose, SA = sialic (neuraminic) acid.

Lectins (proteins and/or glycoproteins of non-immune origin that agglutinate cells, from seeds of Robinia pseudoacacia), M 100,000. Purified by pptn with ammonium sulfate and dialysis then chromatographed on DE-52 DEAE-cellulose anion-exchanger, hydroxylapatite and Sephacryl S-200. [Wantyghem et al. Biochem J 237 483 1986.]... 

Some alcohols, arylamines, and phenols are sulfated. The sulfate donor in these and other biologic sulfation reactions (eg, sulfation of steroids, glycosaminoglycans, glycolipids, and glycoproteins) is adenosine 3 -phos-phate-S -phosphosulfate (PAPS) (Chapter 24) this compound is called active sulfate. ... 

Preobrazhensky AA, Dragan S, Kawano T, et al. Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region. J Immunol 2000 165 5295-303. 

Batinic D, Robey FA. The V3 region of the envelope glycoprotein of human immunodeficiency virus type 1 binds sulfated polysaccharides and CD4-derived synthetic peptides. J Biol Chem 1992 267 6664-6671. 

The syndrome of IgMk paraproteinemia and sensory ataxia is usually encountered in elderly men. Nerve biopsy in these patients shows focal abnormalities in compaction of PNS myelin lamellae, and their IgM paraprotein recognizes epitopes of myelin-associated glycoprotein (MAG) and sulfate-3-glucuronyl paragloboside [24,42]. 

GM1-gangliosidosis, Morquio B GM1-ganglioside galactose-rich fragments of glycoproteins GM1 ganglioside Keratan sulfate... 

CI2(PCy3)2RuCHPh Polymerization to Generate Analogs of Sulfated Glycoproteins... 

Fig. 18. Sulfated carbohydrates were polymerized under emulsion conditions using the defined ruthenium catalyst to provide glycoprotein mimics... 

Fig. 19. The sulfated glycoprotein mimics were tested for biological activity against the se-lectin family of proteins, which are involved in the inflammatory response. These results suggest that length may be a factor in the selectivity of polymers for different proteins...

There have been several studies that underscore the importance of unbound concentration in cell-based studies of receptor function. In a model study of the effect of plasma protein binding on the renal transport of organic anions using the expression of various organic anion transporters (OATPs) in Xenopus oocytes, the transport of ochratoxin A, methotrexate, and estrone sulfate was found to be strongly inhibited by the addition of human serum albumin to the culture medium [16]. Similarly, the addition of oq-acid glycoprotein was found to reverse the blockade of sodium-ion current by cocaine in a preparation of cardiac myocytes [17]. 

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