Glycoprotein receptor

LDL (apo B-lOO, E) receptors occur on the cell surface in pits that are coated on the cytosolic side of the cell membrane with a protein called clathrin. The glycoprotein receptor spans the membrane, the B-lOO binding region being at the exposed amino terminal end. After binding, LDL is taken up intact by endocytosis. The apoprotein and cholesteryl ester are then hydrolyzed in the lysosomes, and cholesterol is translocated into the cell. The receptors are recycled to the cell surface. This influx of cholesterol inhibits in a coordinated manner HMG-CoA synthase, HMG-CoA reductase, and, therefore, cholesterol synthesis stimulates ACAT activ-... 

Specific proteins on the surface of virus particles, e.g. the haemagglutinins of influenza viruses (Fig. 3.8), mediate their adherence to glycoprotein receptors in the plasma membrane of host cells. Viruses make use of a variety of membrane glycoproteins as... 

Amino acid receptors Monoamine receptors Lipid receptors Purine receptors Neuropeptide receptors Peptide hormone receptors Chemokine receptors Glycoprotein receptors Protease receptors Metabotropic glutamate and GABAb receptors Adrenoceptors, dopamine and 5-HT receptors, muscarinic and histamine receptors Prostaglandin, thromboxane and PAF receptors Adenosine and ATP (P2Y) receptors Neuropeptide Y, opiate, cholecystokinin VIP, etc. Angiotensin, bradykinin, glucagon, calcitonin, parathyroid, etc. Interleukin-8 TSH, LH/FSH, chorionic gonadotropin, etc. Thrombin... 

Four diastereoisomers of isoxazolinol 432 have been prepared via [3 + 2] dipolar cycloadditions of nitrile oxides. The ring 45,55 isomer shows the configuration of an isolated metabolite of roxifiban, a platelet glycoprotein receptor antagonist (470). 

Clopidogrel Antiplatelet, inhibits expression of glycoprotein receptors to... 

Glycoprotein receptors on the platelet membrane mediate the adhesion of platelets to damaged blood vessels. The interaction of platelets with von Willebrand... 

This polyionic structure can provide protection against HIV infection by binding to the gpl20 glycoprotein receptor on the vims surface. The normal course of infection of healthy cells with HIV begins when the gpl20 protein on the surface of the vims binds to the CD4 receptor on the surface of the healthy cell [71b]. 

T. Wileman, R. L. Boshans, P. Schlesinger, and P. Stahl, Monensin inhibits recycling of macrophage mannose-glycoprotein receptors and ligand delivery to lyso-somes, Biochem. J. 220 665-675 (1984). 

Abciximab was the first commercially available GPIIb/llla receptor inhibitor. Abciximab is a monoclonal Fab immunoglobulin fragment that binds to the glycoprotein receptor on the platelet membrane. The half-life of abciximab... 

These are potent platelet inhibitors used to prevent the binding of fibrinogen to glycoprotein receptors on the platelet surface that inhibit the final common pathway for platelet aggregation, It is given in combination with aspirin and heparin to prevent clotting before and during invasive heart procedures. 

The platelet receptor-endothelial matrix protein interactions have been well characterized. Under high shear conditions, this attachment is mediated by the binding of von Willebrand Factor (vWF) to the glycoprotein receptor GPlb-lX (27). Secondary attachment between platelets results in thrombus formation, which is caused by Fg or vWF-mediated crosslinking of GPl lb-111a receptors on adjacent... 

Badawy SI, Williams RC, Gilbert DC. Effect of different acids on solid state stability of an ester prodrug of a Ilb/IIIa glycoprotein receptor antagonist. Pharm Dev Technol 1999 4(3) 325-331. 

Howard SP, Buckley JT (1982) Membrane glycoprotein receptor and hole-forming properties of a cytolytic protein toxin. In Biochemistry 21 1662—1667. 

Abbreviations PCI = primary coronary intervention UA = unstable angina NSTEMI = non-ST-segment myocardial infarction Ml = myocardial infarction GP = glycoprotein receptor UFH = unfractionated heparin LMWH = low-molecular-weight heparin. 

Glabe, C.G. and Vacquier, V.D. (1978). Egg surface glycoprotein receptor for sea urchin sperm bindin. Proc. Natl. Acad. Sci. 75 881-885. 

---