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Glycoprotein platelet receptor antagonists

PTCA, unstable angina, non-Qwave MI Glycoprotein Ilb/IIIa platelet receptor antagonists Abciximab Eptifibatide Tirofiban Reduce infarction, revascularization, death (composite) EPIC EPILOG PRISM PRISM-PLUS PURSUIT RESTORE >33,000 12... [Pg.4]

Junghans U, Siebler M. Cerebral microembohsm is blocked by tirofiban, a selective nonpeptide platelet glycoprotein Ilb/nia receptor antagonist. Circulation 2003 107 2717-2721. [Pg.116]

Four diastereoisomers of isoxazolinol 432 have been prepared via [3 + 2] dipolar cycloadditions of nitrile oxides. The ring 45,55 isomer shows the configuration of an isolated metabolite of roxifiban, a platelet glycoprotein receptor antagonist (470). [Pg.94]

Atwater BD, Roe MT, Mahaffey KW. Platelet glycoprotein Ilb/IIIa receptor antagonists in non-ST segment elevation acute coronary syndromes a review and guide to patient selection. Drugs. 2005 65 313-324. [Pg.317]

Cook NS, Zerwes H-G, Tapparelli C et al. (1993) Platelet aggregation and fibrinogen binding in human, rhesus monkey, guinea-pig, hamster and rat blood activation by ADP and thrombin receptor peptide and inhibition by glycoprotein Ilb/IIIa antagonists. Thromb Haemostasis 70 531-539... [Pg.314]

Cox, D.S. Kleiman, N.S. Boyle, D.A. Aluri, J. Parchman, 89. G. Holdbrook, F. Fossler, M.J. Pharmacokinetics and pharmacodynamics of argatroban in combination with a platelet glycoprotein IIB/IIIA receptor antagonist in patients undergoing percutaneous coronary intervention. [Pg.2815]

Ferguson JJ, Zaqqa M. Platelet glycoprotein Ilb/IIIa receptor antagonists. Drugs 1999 S8 965-82. [Pg.95]

Rare cases of acute profound thrombocytopenia (i.e., platelet count <20,000/mm ) have been reported with the glycoprotein Ilb/IIIa receptor antagonist abciximab. ° Although the mechanism is unknown, it is thought that abciximab binding to the glyco-... [Pg.1884]

Hetero Diels-Alder-Biocatalysis approach for the synthesis of (S)-3- 2-[(methyl-sulfonyl) oxy]ethoxy -4-(triphenylmeth-oxy)-l-butanol methanesulfo-nate successful application of an enzyme resolution process Multi-kilo resolution of XU305, a key intermediate to the platelet glycoprotein Ilb/IIIa receptor antagonist roxifiban via kinetic and dynamic enzymatic resolution... [Pg.10]

Multi-Kilo Resolution of XU305, a Key Intermediate to the Platelet Glycoprotein llb/llla Receptor Antagonist Roxifiban via Kinetic and Dynamic Enzymatic Resolution... [Pg.365]

Eptifibatide is a reversible inhibitor of the glycoprotein Ilh/nia receptor, an integrin on the surface of platelets that serves as a key regulator of platelet aggregation. Glycoprotein Ilb/IIIa receptor antagonists help to prevent platelet-induced occlusion of coronary stents. The answer is (E). [Pg.313]

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Glycoprotein- -receptors

Platelet glycoprotein

Platelet glycoprotein Ilb/IIIa receptor antagonists

Platelets receptors

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