Platelet glycoprotein Ilb/IIIa receptor antagonists

Atwater BD, Roe MT, Mahaffey KW. Platelet glycoprotein Ilb/IIIa receptor antagonists in non-ST segment elevation acute coronary syndromes a review and guide to patient selection. Drugs. 2005 65 313-324. 

Ferguson JJ, Zaqqa M. Platelet glycoprotein Ilb/IIIa receptor antagonists. Drugs 1999 S8 965-82. 

Hetero Diels-Alder-Biocatalysis approach for the synthesis of (S)-3- 2-[(methyl-sulfonyl) oxy]ethoxy -4-(triphenylmeth-oxy)-l-butanol methanesulfo-nate successful application of an enzyme resolution process Multi-kilo resolution of XU305, a key intermediate to the platelet glycoprotein Ilb/IIIa receptor antagonist roxifiban via kinetic and dynamic enzymatic resolution... 

Rare cases of acute profound thrombocytopenia (i.e., platelet count <20,000/mm ) have been reported with the glycoprotein Ilb/IIIa receptor antagonist abciximab. ° Although the mechanism is unknown, it is thought that abciximab binding to the glyco-... 

Eptifibatide is a reversible inhibitor of the glycoprotein Ilh/nia receptor, an integrin on the surface of platelets that serves as a key regulator of platelet aggregation. Glycoprotein Ilb/IIIa receptor antagonists help to prevent platelet-induced occlusion of coronary stents. The answer is (E). 

In addition, Asano et al. have reported that DKR of amino acid amides, such as alanine amide, could be performed by using a combination of two enzymes, o-aminopeptidase and a-amino-s-caprolactam racemase, yielding the corresponding o-amino acids. A lipase-catalysed hydrolysis has constituted the key step of a total synthesis of roxifiban, a potent antagonist of the platelet glycoprotein Ilb/IIIa receptor. The DKR of an isobutyl ester to form the corresponding acid in both high yield and enantioselectivity is depicted in Scheme 3.46. 

PTCA, unstable angina, non-Qwave MI Glycoprotein Ilb/IIIa platelet receptor antagonists Abciximab Eptifibatide Tirofiban Reduce infarction, revascularization, death (composite) EPIC EPILOG PRISM PRISM-PLUS PURSUIT RESTORE >33,000 12... 

Cook NS, Zerwes H-G, Tapparelli C et al. (1993) Platelet aggregation and fibrinogen binding in human, rhesus monkey, guinea-pig, hamster and rat blood activation by ADP and thrombin receptor peptide and inhibition by glycoprotein Ilb/IIIa antagonists. Thromb Haemostasis 70 531-539... 

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