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Platelet glycoprotein Ilb/IIIa receptor

Lefkovits J., Plow E. F., Topol E. Platelet glycoprotein Ilb/IIIa receptors in cardiovascular medicine. N Engl J Med 1995 332, 1553-9. [Pg.163]

C. Aspirin inhibits platelet cyclooxygenase. Abciximab, a monoclonal antibody, binds to and inhibits the platelet glycoprotein Ilb/IIIa receptor. Dipyridamole inhibits platelet cyclic AMP phosphodiesterase and raises cyclic AMP levels. Eptifibatide binds to the glycoprotein Ilb/IIIa complex. [Pg.266]

Atwater BD, Roe MT, Mahaffey KW. Platelet glycoprotein Ilb/IIIa receptor antagonists in non-ST segment elevation acute coronary syndromes a review and guide to patient selection. Drugs. 2005 65 313-324. [Pg.317]

Bates, E. R., McGillem, M. J., Mickelson, J. K, Pitt, B., and Mancini, G. B. (1991). A monoclonal antibody against the platelet glycoprotein Ilb/IIIa receptor complex prevents platelet aggregation and thrombosis in a canine model of coronary angioplasty. Circulation 84, 2463-2469. [Pg.406]

EPILOG Investigators (1997). Platelet glycoprotein Ilb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization. N. Enol. J. Med. 336, 1689-1696. [Pg.406]

Platelet glycoprotein Ilb-IIIa receptor binding is given as fmol 125I-fibrinogen/108 platelets or 125I-fibrinogen molecules bound per platelet. [Pg.264]

Coller BS, Folts JD, Scudder LE, Smith SR (1986) Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein Ilb/IIIa receptor in an experimental animal model. Blood 68 783-786... [Pg.317]

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3, which binds to the platelet glycoprotein Ilb/IIIa receptor and inhibits platelet aggregation (1). [Pg.3]

The EPIC Investigation. Use of a monoclonal antibody directed against the platelet glycoprotein Ilb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 1994 330(14) 956-61. [Pg.7]

Ferguson JJ, Zaqqa M. Platelet glycoprotein Ilb/IIIa receptor antagonists. Drugs 1999 S8 965-82. [Pg.95]

Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) Study Investigators. Inhibition of the platelet glycoprotein Ilb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. N Engl J Med 1998 338 1488-1497. [Pg.317]

Hetero Diels-Alder-Biocatalysis approach for the synthesis of (S)-3- 2-[(methyl-sulfonyl) oxy]ethoxy -4-(triphenylmeth-oxy)-l-butanol methanesulfo-nate successful application of an enzyme resolution process Multi-kilo resolution of XU305, a key intermediate to the platelet glycoprotein Ilb/IIIa receptor antagonist roxifiban via kinetic and dynamic enzymatic resolution... [Pg.10]

Abciximab is a monoclonal antibody that reversibly inhibits the binding of fibrin and other ligands to the platelet glycoprotein Ilb/IIIa receptor, a cell surface protein that is involved in platelet cross-linking. Eptifibatide and tirofiban also reversibly block the glycoprotein llb/IIIa receptor. [Pg.308]

Lefkovits J, Ivanhoe RJ, Cahff RM, et al. for the EPIC Investigators. Effects of platelet glycoprotein Ilb/IIIa receptor blockade by a chimeric monoclonal antibody (abciximab) on acute and 6-month outcomes after percutaneous transluminal coronary angioplasty for acute myocardial infarction. Am J Cardiol 1996 77 1045-1051. [Pg.107]

In addition, Asano et al. have reported that DKR of amino acid amides, such as alanine amide, could be performed by using a combination of two enzymes, o-aminopeptidase and a-amino-s-caprolactam racemase, yielding the corresponding o-amino acids. A lipase-catalysed hydrolysis has constituted the key step of a total synthesis of roxifiban, a potent antagonist of the platelet glycoprotein Ilb/IIIa receptor. The DKR of an isobutyl ester to form the corresponding acid in both high yield and enantioselectivity is depicted in Scheme 3.46. [Pg.169]

Aggarwal, R.K., Ireland, D.C., Azrin, M.A., et al. Antithrombotic potential of polymer-coated stents eluting platelet glycoprotein Ilb/IIIa receptor antibody. Circulation 94, 3311-3317 (1996)... [Pg.476]

See other pages where Platelet glycoprotein Ilb/IIIa receptor is mentioned: [Pg.373]    [Pg.119]    [Pg.264]    [Pg.192]    [Pg.228]    [Pg.406]    [Pg.215]    [Pg.261]    [Pg.317]    [Pg.2810]    [Pg.412]    [Pg.423]    [Pg.1845]    [Pg.178]    [Pg.1703]   
See also in sourсe #XX -- [ Pg.3 , Pg.285 ]



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