Glycomes

Glycomer-631 (6) is a terpolymer produced by the bulk polymerisation of a mixture of 60% glycoHde, 14% 2,5- -dioxanone, and 26% trimethylene carbonate. The suture is distributed under the trade name Biosyn. It is claimed to retain approximately 40% of its strength three weeks after implantation and to be absorbed completely in 90 to 110 days. 

Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, 4222, Australia m.vonitzstein griffith.edu.au... 

Developments in the new field of glycomics are likely to provide much new information on the roles of sugars in health and disease and also indicate targets for drug and other types of therapies. 

Volume 417. Functional Glycomics Edited by Minoru Fukuda... 

T. Feizi, F. Fazio, W. Chai, and C.-H. Wong, Carbohydrate microarrays—anew set of technologies at the frontiers of glycomics, Curr. Opin. Struct. Biol., 13... 

In most cases, the precise functions of polysaccharides are not known even their primary sequences are very hard to determine using current analytical techniques. Thus, a major challenge is to crack the carbohydrate code and determine the structures and functions of all the polysaccharides found on human cells. Terms such as glycomics have already been coined to describe such global efforts. 

Volume 36 will be dedicated to carbohydrate-based vaccines and to the utilization of the azide functionality in chemical and biological areas of the glycosciences. There are recent reports on interesting applications of azides in this area, and as starting materials for a variety of important bioactive carbohydrates. Hence, the synthesis, reactivity and application of azides in glycomics will also be included in this volume. 

Fig. 1 Glycan array analysis of codakine as measured by fluorescence intensity (glycan array v3.0 at Consortium for Functional Glycomics). Purified codakine from white clams was purified with Alexa Fluor 488 Protein Labeling Kit (Molecular Probes , Invitrogen) and tested on glycan array v3.0 at Consortium for Functional Glycomics.

Rao, N., Meldal, M., Bock, K., and Hindsgaul, O. Library of glyco-peptides useful for identification of cell adhesion inhibitors, Glycomed Corp., 664, 303 [5,795,958], U.S. Patent 1-28, Califomia/USA. 

Kasai, K Oligosaccharide specificity of galectins a search by frontal affinity chromatography. Biochim Biophys Acta 2002, 1572, 232-254. Hirabayashi, J., Arata, Y, Kasai, K. Glycome project concept, strategy and preliminary application to Caenorhabditis elegans. Proteomics 2001, 1, 295-303. 

Freeze HH (2006) Genetic defects in the human glycome. Nat Rev Genet 7 537-551... 

C. R. Bertozzi Chemistry in living systems a new tool for probing the glycomes Y. Ito Synthesis and functional envelopes of glycoprotein glycan chains... 

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