Glyceryl trinitrate

Glyceryl trinitrate overdose should be treated with the patient s head lowered. Other measures include respiration maintenance, use of plasma expanders, and electrolyte balance. Withdrawal of heparin treatment or dose reduction should be performed with the overdose of heparin. Protamine sulfate may be used to reduce severe bleeding. Heparin should be used with caution with glyceryl trinitrate, aprotinine, alcohol, tobacco, and ACE inhibitors. Nifedipine should be used with care when coadministering with immunosuppressants, magnesium salts, tobacco, digoxin, antineoplastics, calcium channel blockers, antihistamines, antifungals, antiepileptics, antiarrhythmics, and alcohol. [Pg.346]

Nitroglycerin. Nitroglycerin (NG), glyceryl trinitrate [55-63-0] is primarily used as an explosive in dynamites and as a plasticizer... [Pg.12]

Esterification with nitric acid includes the industrially important reactions with glycerol to form glyceryl trinitrate (nitroglycerin), and with cellulose to form cellulose nitrate (nitrocellulose)... [Pg.279]

Glyceryl trinitrate is used in medicines for its effects on blood flow. Physicians use it as a coronary vasodilator for their heart patients. [Pg.59]

The transdermal permation of glyceryl trinitrate encapsulated in AOT-reversed micelles was compared with that of an aqueous solution, and an enhancement in permeation was found as well as the absence of skin irritation [161]. [Pg.488]

The formation of glyceryl-2-nitrate from glyceryl trinitrate by Phanerochaete chrysospo-rium (Servent et al. 1991)... [Pg.51]

Zhang YZ, ST Sundaram, A Sharma, BW Brodman (1997) Biodegradation of glyceryl trinitrate by Penicil-lium corylophilum Dierckx. Appl Environ Microbiol 63 1712-1714. [Pg.679]

On the other hand, insufficient NO production also causes serious medical problems. Many diseases such as hypertension, atherosclerosis and restenosis involve a deficiency of NO production. Therefore, a compound that can release NO under specific conditions can be used therapeutically to palliate NO underproduction. In fact, the best known NO donor, glyceryl trinitrate, has been used for over a century to relieve acute attacks of angina pectoris. [Pg.16]

Fig. 2.1 Commonly used organic nitrates and nitrites. GTN, glyceryl trinitrate ISDN, isosorbide dinitrate IAN, isoamyl nitrite IBN isobutyl nitrite.

Benjamin, N., Dutton, J. A. E., Ritter, J. M., Human vascular smooth muscle cells inhibit platelet aggregation when incubated with glyceryl trinitrate evidence for generation of nitric oxide. Br. J. Pharmacol. 102 (1991), p. 847-850... [Pg.48]

Salvemini, D., Mollace, V., Pistelli, A., Anggard, E., Vane, J., Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by E. coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA 89 (1992), p. 982-986... [Pg.48]

Needleman, P., Harkey. A. B., Role of endogenous glutathione in the metabolism of glyceryl trinitrate by isolated perfused rat liver. Biochem. Pharmacol. 20 (1971), p. 1867-1876... [Pg.49]

Salvemini, D., Pistelli, A., Vane, J., Conversion of glyceryl trinitrate to nitric oxide in tolerant and... [Pg.49]

Servent, D., Delaforge, M., Ducrocq, C., Mansuy, D., Lenfant, M., Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate involvement of cytochrome P-450. Biochem. Biophys. Res. Commun. 163 (1989),... [Pg.49]

Inhibitors of cytochrome P-450 reduce cyclic GMP stimulation by glyceryl trinitrate in LLC-PKi kidney epithelial cells. Naunyn Schmiedebergs Arch. Pharmacol. 342 (1990), p. 616-618... [Pg.49]

MacDonald, B. J., Bennett, B. M., Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450. Biochem. Pharmacol. 45 (1993),... [Pg.50]

O Byrne, S., Shirodaria, C., Millar, T., Stevens, C., Blake, D., Benjamin, N., Inhibition of platelet aggregation with glyceryl trinitrate and xanthine oxidoreductase. J. Pharmacol. Exp. Ther. 292 (2000), p. 326-330... [Pg.51]

Kawamoto, J. H., McLaughlin, B. E., Brien, J. F., Marks, G. S., Nakatsu, K., Biotransformation of glyceryl trinitrate and elevation of cyclic GMP precede glyceryl trinitrate-induced vasodilation. J. Cardiovasc. Pharmacol. 15 (1990), p. 714-719... [Pg.52]

Torfgard, K. E., Ahlner, )., Effect of a low dose of dipyridamole on glyceryl trinitrate tolerance in healthy volunteers. J. Cardiovasc. Pharmacol. 21 (1993), p. 516-521... [Pg.53]

Benzofuroxans (2), benzodifuroxan (37), and benzotrifuroxan (38) are systems that have long been known [6-8,10,11]. Early studies showed that 37 is a potent in vivo and in vitro vasodilator, as are its furazanobenzofuroxan and thiazolobenzofuroxan analogues [26]. Structural comparison between 37 and the extended glyceryl trinitrate (GTN) conformation has shown a close similarity in the relative position between 1 and 3 positioned NO2 moieties in GTN and the 0-N+-0 substructures in the furoxan... [Pg.140]

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