Glucose load studies

METABOLIC AND GLUCOSE LOAD STUDIES IN URIC ACID, OXALIC AND HYPERPARATHYROID STONE FORMERS... 

There are limitations in the use of FDG for viability assessment. Normal myocardium (normal perfusion and normal metabolism) in diabetics may not take up FDG due to insulin resistance associated with elevated free fatty acids in blood. Consequently, there is no FDG uptake anywhere in the heart and the study is uninterpretable. Flowever, giving insulin intravenously at the time of glucose loading enhances myocardial uptake, reduces free fatty acids in blood, and provides diagnostic images. 

For special purposes the effect of blood glucose lowering agents is studied in glucose loaded animals. Rabbits of either sex weighing 3.0-4.5 kg are treated either once (0.5 h after test compound) or twice (0.5 and 2.5 hours after test compound) orally with 2 g glucose/kg body weight in 50 % solution. 

Subsequent experiments were all performed using the waU-jet ceU. In these studies, a number of hospitalized patients with different pathologies (but aU subjected to an oral glucose load) were monitored. The one-point in vivo calibration method was adopted, assuming that the constant value of current observed before the glucose load was proportional to the concentration measured in the blood. This implies a linear relation between the biosensor... 

In the course of our screening studies on the bioactive constituents of medicinal foodstuffs, the saponin fraction obtained from the roots of Japanese sugar beet was found to show an inhibitory effect on the increase of serum glucose levels in oral glucose-loaded rats. 

Absorbed chromium is principally excreted in the urine with a small amount being eliminated in hair, sweat, and bile. Urine levels appear to be a useful indicator of chromium intake when dietary intake is >40 p.g/day however, excretion becomes constant when the intake is <40 jt,g/day. Urine chromium levels have been reported to be increased in diabetes, glucose loading, strenuous running, and physical trauma. Anderson has stated that urine chromium does not appear to be related to blood glucose, insulin, lipid, or any other studied clinical variables [11]. 

The first study was performed in newborns idiose mothers received during delivery an infusion of 300 ml glucose, which gave the babies an intravenous glucose load. Blood glucose, plasma free fatty acids (PFA), Insulin and HGH were determined in the mother at delivery, in the cord blood and in the newborn at age of 2 hours. The various groups studied and part of the results are shown in Table 1. 

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