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Gilead Sciences

D VISTIDE (Pharmacia USA Vistide (Gilead Science) Upjohn)... [Pg.467]

Vistide Cidofovir injection Gilead Sciences Cytomegalovirus retinitis in AIDS patients... [Pg.695]

Gilead Sciences—Randall Britton Corkey, Randall Halcomb, Richard Mackman, Paul Roethle... [Pg.1]

Editor Manoj C. Desai Medicinal Chemistry Gilead Sciences, Inc. Foster City California... [Pg.380]

The neuramidase inhibitor oseltamivir phosphate was discovered by Gilead Sciences and developed by Roche Pharmaceuticals under the name of Tamiflu (Scheme 5.13) to be used as an orally active antiviral compound for prevention and treatment of influenza infections. Because of the recent emergence of the avian flu, the demand for Tamiflu has gained momentum. Two industrially feasible syntheses are known, starting from (—)-shikimic acid and (—)-quinic acid, respectively (Scheme 5.13) [45]. [Pg.116]

The three commercially available AmB formulations differ in their morphology, their composition, and, consequently, their biological activity. AmBisome (developed by Nexstar Pharmaceuticals, commercially available from Gilead Sciences) is a true liposome formulation, consisting of small, unilamellar vesicles (9). Their small size confers a prolonged circulation time... [Pg.94]

For the purposes of comparison, commercial AmB-lipid formulations were obtained as follows. Amphotec was obtained from Intermune (U.S.A.). AmBisome and Abelcet were kind gifts from Gilead Sciences (Foster City, California, U.S.A.) and Zedeus Pharma (Versailles, France), respectively. Ampholiposomes (cationic oligolameller liposomes containing AmB) were supplied by the Pharmacie Centrale des Hopitaux (Paris, France). [Pg.96]

Corey, E. J. Kim, C. U. J. Am. Chem. Soc. 1972, 94, 7586. Choung U. Kim now works at Gilead Sciences Inc., a company specialized in antiviral drugs in Foster City, CaUfomia, where he co-discovered oseltamivir (Tamiflu). [Pg.163]

Gilead Sciences Press release 22 Febmary 2010. Available at http //www. gilead.com. [Pg.140]

Ambisome , Daunoxome , liposomal amphotericin B and daunorubicin citrate injection. Liposomal lurtotecan in phase I clinical trials. Gilead Sciences Inc., Foster City, CA. [Pg.371]

Several other important compounds found in the common aromatic amino acid pathway whose overproduction has been studied are shikimic acid (61) and, to a lesser extent, quinic acid (62) (Scheme 19.41).323 Both 61 and 62 are naturally occurring, highly functionalized carbocyclic rings with asymmetric centers, which can be used as starting material for the synthesis of GS4104 (63), a neuraminidase inhibitor discovered by Gilead Sciences and developed by Roche Pharmaceuticals under the trade name of Tamiflu .324 325 Manipulation of the aromatic amino acid pathway in E. coli has allowed for numerous strains to be assembled that produce both 61 and 62 as well as other intermediates.326 327 As reported by Chandran and co-workers, an E. coli strain has been constructed that synthesized 87 g/L (0.5m) of 61 in 36% (mol/mol) yield with a maximum productivity of 5.2 gL- lr1.328... [Pg.386]

USAN Tenofovir (TDF) Trade name Viread Gilead Sciences Launched 2001... [Pg.4]

Sun S, Technology evaluation SELEX, Gilead Sciences Inc, Curr. Opin. Mol. Ther., 2 100-105, 2000. [Pg.520]

Daunorabicin (DaunoXome, Gilead Sciences, Inc.) Doxorubicin (Doxil/Caelyx, Ortho Biotech ProductsLP/Sequus Pharmaceuticals) Amphotericin B (Ambisome/Abelcet, Fujisawa Healthcare, Wyeth Pharmaceuticals) Doxorubicin (Myocet/Evacet, Sopherion/ Liposome Company) Hepatitis A virus envelope proteins (Epaxal, Berna Biotech) Influenza virus (Inflexal V, Berna Biotech) Verteporfin (Visudyne, Novartis Ophthalmics) Kaposi s sarcoma Kaposi s sarcoma Fungal infections in immunocompromised patients Metastatic breast cancer Hepatitis A Influenza Age-related macular degeneration... [Pg.483]

Replication inhibitor Tenofovir PMPA Gel Gel Gilead Sciences Phases II/IIb... [Pg.844]

Daunorubicin DaunoXome DSPC, cholesterol Kaposi s sarcoma Gilead Sciences... [Pg.1263]

Amphotericin B AmBisome (lyophihzed product) HSPC, cholesterol, DSPG, a-tocopherol, sucrose, disodium succinate Fungal infections Gilead Sciences... [Pg.1263]

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See also in sourсe #XX -- [ Pg.2 ]

See also in sourсe #XX -- [ Pg.29 , Pg.75 ]



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