Genomic and Proteomic Databases

Human Genome Central. Ensembl, European EMBL-EBI, Sanger Institute, U.K. URL http //www.ensembl.org/ 

International Nucleotide Sequence Database. URL http // www.ddbj.nig.ac.jp/. A joint compilation of heterogeneous sequence data into a redundant database. New and updated data shared daily by DNA Database of Japan (DDBJ). European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBD- Cambridge, U.K. URL http // www.ebi.ac.uk/Databases/. GenBank. NCBI. URL http // www.ncbi.nlm.nih.gov/Genbank/GenbankSearch.html. 

RCSB Protein Data Bank (PDB). Research Col laboratory for Structural Bioinformatics (RCSB). URL http //www.rcsb.org/ pdb/. Repository for the processing and distribution of experimentally determined three-dimensional macromolecular structure data. 

Universal Protein Knowledgebase (UniProt). European Bioinformatics Institute (EBI), Swiss Institute of Bioinformatics (SIB), Protein Information Resource (PIR), Georgetown Univ. URL http //www.uniprot.org. Central repository of protein sequence and function created by joining the information contained in Swiss-Prot, TrEMBL, and PIR. A central access point for extensive curated protein information, including function, classification, and cross-reference. 

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Genomics, functional genomics and proteomics, with their enabfing technologies (biological and biochemical methods, instrumentation, automation techniques and databases), are revolutionizing research in biology and pharmaceutical and medical fields. 

The collecting, organizing, and indexing of sequence information into a database provides the scientist with a wealth of information on human genome and proteome. What makes this database so useful and powerful is its analysis, which may lead to information indicating that the sequence of DNA in question does not always constitute only one gene it may contain several genes. 

This site gives registered users access to a collection of programs and databases to aid genomic and proteomic research. 

X-ray diffraction was the primary method used to investigate protein structure in early years. However, other physical, chemical, and biological methods are now used and a number of databases of protein structure have been developed. It is expected that genomics and proteomics (see Chapters 7 and 36) will greatly expand the number of sequenced proteins. 

Biological databases Sequence alignment Gene prediction Molecular phylogenetics Structural bioinformatics Genomics and proteomics... 

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