Function create

With the advent of molecular biology and the ability to express transfected genes (through transfection with cDNA) into surrogate cells to create functional recombinant systems has come a revolution in pharmacology. 

Figure 4.6. Recombinational cloning (RC). A. Cloning of PCR products using the attB + attP > attL + attR reaction catalyzed by Int and IHF. The result is an Entry Clone that can be used to create functional vectors. B. Conversion of an Entry Clone to a functional vector using the attL + attR > attB + attP reaction catalyzed by Int, Xis and IHF. A wide variety of functional vectors can be constructed by using a Destination Vector with the appropriate promoters and tags.

Modification Reagent that can create functional groups able to couple with reactive group 2 of the hetero bifunctional crosslinking agent... 

In this section, the chemistry and structure of nucleic acids and oligonucleotides is discussed with a view to creating functional conjugates with detectable molecules. The corresponding strategies and protocols associated with DNA or RNA modification and conjugation can be found in Chapter 27. 

Just as pre-mRNA molecules are chemically modified to create functional mRNA (figure 13.2), nascent proteins may be chemically modified to create fully functional molecules. There are two general mechanisms at work here proteolytic cleavage and covalent modification. 

P2 The long-term goal of the proposed research is to create functional model complexes of metalloprotein active sites. (From Flouser, 2001)... 

B. Differential Splicing of Titin Exon Shuffling Creates Functionally... 

This discussion clearly demonstrates that drugs do not create functions, but merely stimulate or inhibit functions already inherent in cells. These pharmacodynamic-related interactions occur at various levels of cellular activity, including ion transport, enzymes, coenzymes, nucleic acids, and numerous other biochemical events yet to be delineated. 

As a starting point for structural cost optimization, Clariant first of all has an optimized production network design that leverages scale effects and regional advantages. Second, a review of truly value-creating functions, processes, and process steps is performed on a regular basis. 

The need to create functional nanosized architectures has led to the design and synthesis of surfactants that can be reversibly switched between two molecular states by incorporating redox-active or light sensitive functionalities.172,173,174,175,176,177,178 In these systems the ability to tune the properties of the surfactant by either controlling the potential applied to... 

Both curves are symmetrical around x1 = 1/2. Create functions to represent the left and right halves of the curves. 

Patenting is expensive but more so is the cost of designing around your patents to create functional equivalents if your competitors are in catch-up mode. 

Walzem, R.L., Dillard, C.J., and German, J.B. 2002. Whey components millennia of evolution create functionalities for mammalian nutrition what we know and what we may be overlooking. Crit. Rev. Food Sci. Nutr. 42, 353-375. 

Bulk grafting of polyolefins with functionalized monomers can be performed by means of conventional processing equipment. Inherently stabilized polyolefins are formed when low concentrations of functionalized monomers are used [218]. Using high concentration levels of the latter, stabilizer masterbatch for blending with undoped polyolefins are created. -Functionalized polyolefins can be prepared by means of the radical grafting more successfully than via copolymerization. 

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