Genome dispensable

Boder E, Sedgwick RP (1958) Ataxia-telangiectasia a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection. Pediatrics 21(4) 526-554 Brown EJ, Baltimore D (2003) Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 17(5) 615-628... 

Ucker DS, Obermiller PS, Eckhart W, Apgar JR, Berger NA, Myers J. Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes. Mol Cell Biol 1992 12 3060-3069. 

Hirsh, A.E., and Fraser, H.B., 2003, Genomic function Rate of evolution and gene dispensability. Nature 421 497 198. 

Many plasmids and bacteriophages have been ingeniously modified to enhance the delivery of recombinant DNA molecules into bacteria and to facilitate the selection of bacteria harboring these vectors. Plasmids are circular duplex DNA molecules occurring naturally in some bacteria and ranging in size from 2 to several hundred kilobases. They carry genes for the inactivation of antibiotics, the production of toxins, and the breakdown of natural products. These accessory chromosomes can replicate independently of the host chromosome. In contrast with the host genome, they are dispensable under certain conditions. A bacterial cell may have no plasmids at all or it may house as many as 20 copies of a plasmid. 

Landry, C.R., Oh, J., Hart, D.L., and Cavalieri, D. 2006a. Genome-wide scan reveals that genetic variation for transcriptional plasticity in yeast is biased towards multi-copy and dispensable genes. Gene 366, 343-351. 

Chromosomally located genes that are unique to Y. pestis and make up the dispensable part of its genome are laterally acquired mobile genomic elements. Until now, there has been no direct evidence of their effect on pathogenicity. Perhaps further analysis of a larger collection of Yersinia strains might further reduce the number of Y. /ie.sf/.s-specific chromosomal fragments. 

Lessons from a small dispensable genome, the mitochondrial genome of yeast... 

Bernardi G. (2005). Lessons from a small, dispensable genome the mitochondrial genome of yeast - review. Gene 354 189-200. 

Genomic Solutions MicroGrid OmniGrid Microcontact printing with solid or quill pins. Spot size and dispense volume dependent upon pin type. www.genomicsolutions.com... 

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