Genome-Wide Scan

There appears to a be a family prostate cancer syndrome and genome-wide scans have identified potential prostate cancer susceptibility loci on chromosomes 1, 2q, 12p, 15q, 16p, and... 

In a genome-wide scan study, a large proportion of the genotyped markers fall into intergenic regions, and are likely to be not relevant for association studies. 

Meta-analysis of the 20 genome-wide scans for linkage to schizophrenia has identified loci on 16 of the auto-somes at which susceptibility genes are likely located[5]. Thus far, there is no evidence for autosomal dominant/ recessive Mendelian-like genes that would account for schizophrenia. Potential risk genes will be discussed in the section Cellular and Molecular Studies. 

Hara, K.Y., Shimodate, N., Ito, M., Baba, T., Mori, H., and Mori, H. (2009) Systematic genome-wide scanning for genes involved in ATP generation in Escherichia coli. Metab. Eh0. 11, 1-7. 

Introduction Candidate Gene Approach Pathway-Based Approach Genome-Wide Scanning Approach... 

Analyzing data derived from a genome-wide scan is a huge statistical endeavor and is beyond the scope of this chapter. There are a few specific analytic issues, however, that are worth mentioning. 

Pros and Cons of the Genome-Wide Scan Approach... 

Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Peris T. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci USA 2001 98 10505-10508. 

Once genotypes have been derived from genome-wide scans, the data can be analyzed so as to determine whether any markers cosegregate with the disease/phenotype. Segregation of alleles is evaluated using linkage... 

DeLisi LE, Sherrington R, Shaw S, Nanthakumar B, Shields G, et al. 2002. A genome-wide scan of 382... 

Kuokkanen S, Gschwend M, Rioux ID, Daly Ml, Terwilliger ID, Tienari PI, Wikstrom I, Palo I, Stein LD, Hudson TI, Lander ES, Peltonen L (1997) Genome wide scan of muldple sclerosis in Einnish muldplex families. Am I Hum Genet 61 1379-87. 

JH, Singer C, Cui iie LJ, Wooten GF, Vieregge P, Prams taller PP, Klein C, Hubble JP, Stacy M, Montgomery E, MacDonald ME, Gusella JF, Myers RH (2001) Genome-wide scan for Pai kuison s disease Tlie GenePD Study. Neurology 57 1124—1126. 

Landry, C.R., Oh, J., Hart, D.L., and Cavalieri, D. 2006a. Genome-wide scan reveals that genetic variation for transcriptional plasticity in yeast is biased towards multi-copy and dispensable genes. Gene 366, 343-351. 

Laitinen T. Daly MJ, Rioux JD, et al A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet 2001 28 87-91. (Ill)... 

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