Genome, concepts

Mushegian, A. (1999). The minimal genome concept. Curr. Opin. Genetics Develop., 9, 709-714. 

When a virus multiplies, the genome becomes released from the coat. This process occurs during the infection process. The present chapter is divided into three parts. The first part deals with basic concepts of virus structure and function. The second part deals with the nature and manner of multiplication of the bacterial viruses (bacteriophages). In this part we introduce the basic molecular biology of virus multiplication. The third part deals with important groups of animal viruses, with emphasis on molecular aspects of animal virus multiplication. 

The biosphere includes ecological niches where microbes peacefully co-exist with their eukaryotic host in the human this includes the concept of the micro-biome [14], which is defined as the totality of microbial organisms that co-habit with human beings. On the other hand, microbial colonization of human mucosal surfaces or prosthetic devices, often results in the development of biofilms, with significant deleterious effects on human health [15]. These are some of the challenges in infectious diseases that reflect the need to maximally utilize genomic sequence information and related sciences to better control microbial disease in human populations, and to develop anti-microbial agents with a better therapeutic index. 

O Assessed primarily genetic (SNP) and genomic (expression) approaches O A concept to provide more patient/disease-specific health care O One drug — many genomes (i.e., different patients)... 

National Institute of Environmental Health Sciences (NIEHS) (2001) Environmental Genome Project Overview, www.niehs.gov/envgenom/concept.htm (accessed May 27, 2002). 

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