Genetic probing

Herzberg, M. (1984) Molecular genetic probe, assay technique, and a kit using this molecular genetic probe. European Patent Application, 0128018. 

Chemical and Genetic Probes—Nanotube-tipped atomic force microscopes can trace a strand of DNA and identify chemical markers that reveal DNA fine structure. A miniaturized sensor has been constructed based on coupling the electronic properties of nanotubes with the specific recognition properties of immobilized biomolecules by attaching organic molecules handles to these tubular nanostructures. In one study, the pi-electron network on the CNT is used to anchor a molecule that irreversibly adsorbs to the surface of the SWNT. The anchored molecules have a tail to which proteins, or a variety of other... 

Genetic Probes of Enzyme Structure Milton J. Schlesinger... 

Krauss RM. Dietary and genetic probes of atherogenic dyslipidemia. Arterioscler Thromb Vase Biol. 2005 25 2265-2272. 

A subtle but important benefit of biotechnology is the use of genetic probes and tests based on the polymerase chain reaction to screen for and identify pathogens in foods. The economics could result in 40 billion/year cost savings as a result of reduced illness. Clearly, these are public benefits from many of the biotechnology-derived products that are currently available and will become available in the next century. As more sophisticated products become available, the benefits should continue to increase. Biotechnology very likely offers the best answer to respond to society s demands for plentiful new food varieties. These foods must be appetizing, nutritious, safe and healthy with minimal envirotunental... 

This book, from its initial conception, had obviously to be limited in the choice of subjects, but we believe it represents a valuable and readily reproducible collection of established and emerging techniques. Such a collection is preceded by a general introductory chapter (Chap. 1) that recalls the history of immunocytochemistry, its basic principles, and its application to the study of neuronal complexity. The methods presented include immunocytochemical localization at light and electronic levels, biochemical characterization, and functional analysis in vivo or ex vivo by novel types of microscopy, as well as protocols for development and production of genetic probes. Although this book is primarily devoted to approaches for analysis of the mammalian brain, a few nonmammalian species are also taken into consideration to demonstrate the importance of alternative animal models in a more comprehensive analysis of central and peripheral neurons. 

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