Genetic predispositions to disease

The challenges to bio-inspired engineering are matty, but the benefits will be tremendous in determining mechanisms of disease, dmg candidates, and clinical molecular diagnostics. Advances will lead not ordy to faster screening and detection of diseases, but also to the tailoring of therapeutics based on an individual s genetic predisposition to disease, or personalized medicine with individualized... 

Allikmets, R, 2000. Simple and complex ABCR Genetic predisposition to retinal disease. Am J Hum Genet 67, 793-799. 

Collinge, J., Palmer, M. S. and Dryden, A. J. Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. Lancet 337 1441-1442,1991. 

There are gradients of health status across income and education (referred to as socioecomic status or SES ) that are not explained by access to health care or other simple explanations [40]. Therefore, it may be of great relevance in the future to understand the role of such factors as sense of control, helplessness, persistent fear and anxiety, diet, exercise, and the impact of the living and social (e.g. family and work) environments in regulating the allostatic systems these factors could cause allostatic systems to operate inefficiently and lead to an acceleration of genetic predispositions towards disease. 

Without regard to therapy, potentially valuable diagnostic tests are available for presymptomatic evaluation of risk of breast cancer due to predisposition from BRCA 1 or BRCA 2 and of colon cancer related to familial adenomatous polyposis (APC gene) or hereditary nonpolyposis mismatch repair genes (MSH 2). Genetic predisposition to Alzheimer disease associated with ApoE4 is neither sufficient nor necessary to lead to the clinical condition, and no definitive therapy is available. 

I am confident that with the approach of the postgenome era, an ever-increasing number of human genes will be discovered and their functions elucidated. Combined with the knowledge of human gene polymorphism, genotyping will allow prediction of the genetic predisposition to certain diseases, such as cancer. The new millennium will usher us in a new era of disease-predictive medicine. 

Whether a bacterial population behaves pathogenically or not will be a function of that component species genetics, the restraints which other members in the community are able to impose, and the result of any overriding selection pressures dictated by environmental factors governing habitat type and host predisposition to disease. 

Nebert DW, Roe AL, Vandale SE, Bingham E, Oakley GG. NAD(P)H quinone oxidoreductase (NQOl) polymorphism, exposure to benzene, and predisposition to disease a HUGE review. Genet Med 2002 4 62-70. 

Fontana, R. J., and Watkins, P. B. Genetic predisposition to drug-induced liver disease. Gastroenterol. Clin. North Am. 24, 811, 1995. 

Q14 It is possible but unlikely. There is evidence of a genetic predisposition to celiac disease and the onset of symptoms can be triggered in susceptible individuals by an environmental event. The amount of gluten that can be taken by a susceptible individual, without provoking symptoms, varies greatly some patients are much more sensitive than others and the immune reactivity... 

This is the first case of this kind associated with ephedrine, and it seems plausible that the patient s previous history indicated a genetic predisposition to vascular disease. 

It s not about genetic predispositions to certain illnesses or conditions. Once you know this one vital secret, you will hold the power to create—and maintain—your own good health. Imagine equipping your body with the tools it needs to ward off cold and flu viruses, heart disease, arthritis, osteoporosis, diabetes, kidney disease, and cancer. And as a bonus, you ll have more energy and feel better than ever, and excess weight will simply melt off ... 

The study of genes that determine human traits is very topical and not without controversy. Identification of genes that comprise the human genome, their function, and their ability to predict disease or a predisposition to disease is central to this research. However, because genetic material in one individual is shared by biological relatives, privacy and confidentiality affect not just the individual who may wish to consent to research participation. The effects of such research and how... 

Restrictive myocardial disease may result from several local or systemic disorders. Amyloidosis, hemochromatosis, scleroderma, carcinoid, sarcoidosis, diabetes, pseudoxanthoma elasticum, and endomyocardial fibrosis have been known to cause restrictive cardiomyopathy. The most common cause of restrictive cardiomyopathy in the industrialized world is amyloidosis, whereas endomyocardial fibrosis is a common cause in tropical areas of the world. There may be a genetic predisposition to idiopathic restrictive cardiomyopathy. ... 

Enzymes are useful in modem medical practice for several reasons. Enzyme assays provide important information concerning the presence and severity of disease. In addition, enzymes often provide a means of monitoring a patient s response to therapy. Genetic predispositions to certain diseases may also be determined by measuring specific enzyme activities. 

---