Clinical consequences

Based on this the concept healthy adherer has been introduced (Simpson et al. 2006). Recently the direct long time survival advantages of improved compliance to EBM based treatments (but not to non-EBM based) has been demonstrated in a very large study (Rasmussen et al. 2007). 

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Another anticonvulsant, formerly used as a hypnotic, is 5-ethyl-5-phenyIhydantoin [631 -07-2] (Nirvanol, Mephenytoin). Its S isomer is stereo-selectively eliminated in most subjects, a fact having clinical consequences with both desired and untoward effects (119). 

The transition between the T and R states of hemoglobin is also deeply involved in the Bohr effect and cooperativity. Therefore stabilization of either of the two stmctures should diminish these effects, which have important physiologic consequences. The clinical consequences of stabilization are not known. 

The individual statins differ with respect to their pharmacological properties, but in general the clinical consequences of this are limited, but may occasionally... 

Proopiomelanocortin (POMC) is the precursor peptide of hormones and neuropeptides expressed in the pituitary and the hypothalamus (adrenocorticotropic hormone (ACTH), lipotropin, a-melanocyte-stimulating hormone (aMSH), yMSH, 3-endorphin, and others). The main clinical consequences of POMC deficiency are adrenal insufficiency (due to absence of ACTH), red hair pigmentation (due to absence of MSH) and severe early-onset obesity (due to the lack of aMSH). 

Pharmacodynamic tolerance to the psychomotor effects of benzodiazepines has been demonstrated after single or multiple doses (File 1985 Greenblatt and Shader 1978 Rosenberg and Chiu 1985). Pharmacodynamic tolerance to the anxiolytic effect (over a 6-month period) has not been demonstrated (Rickels et al. 1983), and clinical experience supports the view that many patients with anxiety disorders require long-term therapy with benzodiazepines or alternative antianxiety agents. An important clinical consequence of tolerance to sedative effects is observed in benzodiazepine overdoses, when patients may initially be... 

The dissolution and ion release from dental silicate cement have been the most investigated characteristics with good reason, for they are central to its clinical performance. Erosion limits its life but release of fluoride has important clinical consequences. 

Most infants have physiologic reflux with no clinical consequence.26 Complications, although rare, include distal esophagitis, failure to thrive, esophageal strictures, and Barrett s esophagus.27... 

Because hyperprolactinemia is often associated with hypogonadism, the goals for management of hyperprolactinemia are to restore the clinical consequences of hypogonadism and reduce its associated risk for osteoporosis44 (Table 43-7). 

Moller H-J (2000). Definition, psychopharmacological basis and clinical evaluation of novel/ atypical neuroleptics Methodological issues and clinical consequences. World Journal of Biological Psychiatry, 1, 75-91. 

Clinical Consequences. 2e Robert Crichton Copyright 2001 John Wiley Sons Ltd ISBNs 0-471-49223-X (Hardback) 0-470-84579-1 (Electronic)... 

From Molecular Mechanisms to Clinical Consequences Second Edition... 

Inorganic biochemistry of iron metabolism from molecular mechanisms to clinical consequences / Robert Crichton with the collaboration of Johan Boelart. .. [et aZ.].—2nd ed. p. cm. 

Heterozygosity for the C282Y mutation of the HFE gene has always been considered to be of no clinical consequence. There are now some studies showing that, as a... 

Microbial Strategies to Overcome the Iron-withholding Imposed by the Host, and its Potential Clinical Consequences... 

Van der Waaij D Colonization resistance of the digestive tract - mechanism and clinical consequences. Nahrung 1987 81 507—517. 

Crichton, R. Inorganic Biochemistry of Iron Metabolism From Molecular Mechanisms to Clinical Consequences , 2nd edn. Wiley Chichester, 2001. 

Fauser, B. and Vanheusden, A. 1997. Manipulation of human ovarian function-physiological concepts and clinical consequences. Endocrine Reviews 18(1), 71-106. 

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