Genetic diseases linkage analysis

Linkage analysis by studying RFLP patterns in two or more generations of family members afflicted with a disease is useful for genetic counseling for the prediction of inherited disease, in spite of its limitations, such as the possibility of genetic recombination or the presence of more than one gene locus in different family members. 

Another area of pathway analysis that benefits from text mining is in de novo pathway generation. This means building a pathway when the cascade is unknown. For example, genetic linkage analysis often finds a gene associated with a disease... 

Hubner N, Wallace CA, Zimdahl H et al 2005 Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet 37 243—253... 

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