Genetic linkage disequilibrium analysis

Walss-Bass C, Escamilla MA, Raventos H, Montero AP, Armas R, et al. 2005. Evidence of genetic overlap of schizophrenia and bipolar disorder Linkage disequilibrium analysis of chromosome 18 in the Costa Rican population. Am J... 

Zavattari P, Deidda E, Whalen M et al. Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations demography, chromosome recombination frequency and selection. Hum Mol Genet 2000 9 2947-2957. 

An alternative approach to the analysis of individual candidate gene variants is to use as the unit of analysis gene haplotypes instead of single SNPs. This overrides the need of knowledge on the functional consequences of genetic variants. Several studies of linkage disequilibrium across the human genome have shown that most... 

Martin ER, Menold MM, Wolpert CM, Bass MP, Donelly SL, Ravan SA, Zimmerman A, Gilbert JR, Vance JM, Maddox LO, Wright HH, Abramson RK, DeLong GR, Cuccaro ML, Peiicak-Vance MA (2000) Analysis of linkage disequilibrium in y-aminobutyric acid receptor subunit genes in autistic disorder. Am J Med Genet 96 43-48. 

Genetic association studies may be either family based, or population based (26,27). Family based studies can use transmission disequilibrium tests (TDT), a test that detects association in the presence of linkage. Population-based tests use analysis of variance (ANOVA) among multiple subgroups. The TDT was first proposed by Spielman and Ewens (28). The basic premise of the TDT is that certain alleles at a locus are disproportionately transmitted Irom parents to an affected offspring therefore the basic sampling unit for the TDT is a nuclear family with at least one affected offspring... 

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