Functional genes homology

Krauss, S., Concordet, J.P., Ingham, P.W. (1993). A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarising activity in zebrafish embryos. Cell 75,1431-1444. 

There are several ways in which structural genomics has promise as a tool for genome annotation and target prioritization. For genes of unknown function, structure can often provide clues to biochemical function. Sequence homology has become a routine method for functional assignment, but even the most... 

Gene Function by Homology to Other Defined Genes, 43... 

Irr does not accumulate in iron replete cells, and is active in iron-limited cells. Secondly, Fur represses iron transport, whereas Irr is a positive effector. Thirdly, we isolated a B. japonicum fur gene homolog that functionally complements an E. coli fur mutant and binds to a Fur-binding DNA consensus sequence. Irr cannot complement the E. coli strain, nor does it have Fur binding activity. 

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