Models gene function

Gene Function Animal model (Anticipated) phenotype of human disease... 

Genetically Engineered Animal Models to Study Gene Functions... 

Some crystallins are (as far as we know) ubiquitous in vertebrates. Of these aA-crystallin is the most abundant and has been used in large-scale phylogenetic analyses, using classic techniques of isolation and sequencing.6 However, it has recently been appreciated that other major crystallins show remarkably taxon-specific patterns of expression (Fig. 1). Furthermore, these taxon-specific crystallins are all identical to enzymes, or else rather recently derived from enzymes (Table I). Some modification in a single functional gene led to the acquisition by the protein product of a dual function as both enzyme and structural lens protein. In this model gene recruitment comes first duplication may or may not follow.7... 

Carmeliet P, Schoonjans L, Kieckens L et al. (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368 419—424 Christie PD, Edelberg JM, Picard MH et al. (1999) A murine model of myocardial thrombosis. J Clin Invest 104 533-539... 

---