Gene Expression and Regulation

Abstract In this chapter we make use of all the material studied so far to construct a few (simple but informative) models for gene expression. As before, we are interested in obtaining useful information regarding both the dynamical and thermodynamical aspects of this phenomenon. [Pg.91]

In the above reactions D represents an empty promoter. Dp denotes a promoter bound by a polymerase (open complex), S corresponds to the substrates out of which the RNA molecule is made, and M is the resulting RNA molecule. [Pg.91]

SantiUm, Chemical Kinetics, Stochastic Processes, and Irreversible Thermodynamics, Lecture Notes on Mathematical ModeUing in the Dfe Sciences, [Pg.91]

Furthermore, no, np, nop, and hm stand for the free promoters, polymerase, polymerase-promoter closed complex, and RNA molecule counts. [Pg.92]

The closed complex is quite unstable as compared with the open one (McClure 1985) a polymerase binds and unbinds several times to the promoter before forming the open complex. This means that the rates corresponding to the chemical reaction in (8.1) are much larger than those corresponding to the reaction in (8.2) kM k, kp. [Pg.92]

The mechanical properties of DNA have attracted the interest of both physicists and biologists because of their relation to many biological events such as DNA transcription, gene expression and regulation, and DNA rephcation. [Pg.132]

This stage involves alteration in gene expression and regulation via cell surface or cytosolic receptors. Most promoters affect gene expression via perturbation of the signal transduction pathways tyrosine kinase, steroid, or G protein linked. The result is cell proliferation. [Pg.278]

SOME METHODS TO EVALUATE GENE EXPRESSION AND REGULATION 15... [Pg.15]

D. W. Nebert and F. J. Gonzalez, Trends Pharmacol. Sci., 6, 160 (1985). Cytochrome P450 Gene Expression and Regulation. [Pg.216]

A number of studies have shown that a-tocopherol has a role in modulation of gene expression and regulation of cell proliferation (Section 4.3.3), suggesting that the potential beneficial effects of vitamin E against heart disease and cancer (Section 4.6.2) may not be because of its antioxidant action. [Pg.115]

Gene Expression and Regulation in Bacteria Life at the Single-Molecule Level... [Pg.440]

Wiltse J (2005) Mode of action inhibition of histone deacetylase, altering WNT-dependent gene expression, and regulation of beta-catenin-developmental effects of valproic acid. Crit Rev Toxicol 35(8-9) 727-738... [Pg.431]

Paz-Elizur, T., Skaliter, R., Blumenstein, S., and Livneh, Z. (1996). Beta, a UV-induc-ible smaller form of the beta subunit sliding clamp of DNA polymerase III of Escherichia coli. I. Gene expression and regulation. J. Biol. Chem. 271, 2482—2490. [Pg.261]

Fatty Acids/Eicosanoids, Gene Expression and Regulation... [Pg.8]

The availability of the cloned genes opens the way for studies on gene expression and regulation by phosphate and other well-known effectors of polyene macrolide biosynthesis. [Pg.570]

Biosynthesis and metabolic engineering Molecular biology, omics, enzymology, gene expression and regulation, biotechnology. [Pg.356]

CAT (cat gene) is an extremely useful and efficient marker/reporter for the study of eukaryotic gene expression and regulation. The principles underlying the applications of the CAT gene as reporter, selectable marker, and/or fusion protein carrier are similar to those for other marker/reporter systems, namely lacZ (jSGal) and bla (ApO (see Sections A and B, this chapter). [Pg.623]

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