Histone methyl transferases

Vandel, L. and Trouche, D. (2000) Physical association between the histone acetyl transferase CBP and a histone methyl transferase. EMBO Rep. 2, 21-26. 

Vaquero, A., Scher, M., Erdjument-Bromage, H., Tempst, P., Serrano, L. and Reinberg, D. (2007) SlRTl regulates the histone methyl-transferase SUV39H1... 

Figure 13.2 (a) Sequential methylation and demethylation of lysines catalyzed by histone methyl transferases (HMTs) and histone demethylases (HDMs), respectively, (b) Sequential methylation and demethylation of arginines catalyzed by HMTs and HDMs, respectively, leading to symmetric and asymmetric dimethylarginines. 

Garagnani P, Pirazzini C, Eranceschi C (2013) Colorectal cancer microenvironment among nutrition, gut microbiota, inflammation and epigenetics. Curr Pharm Des 19 765-778 Nencioni A, Bruzzone S, Del Rio A (2013) Editorial NAD+ biosynthesis and signaling as an emerging area in medicinal chemistry. Curr Top Med Chem 13 2905-2906 Teperino R, Schoonjans K, Auwerx J (2010) Histone methyl transferases and demethylases can they link metabolism and transcription Cell Metab 12 321-327 Rajendran P, Williams DE, Ho E, Dashwood RH (2011) Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol 46 181-199... 

Histone methylation is a common posttranslational modification fond in histones. Histone methylations have been identified on lysine and arginine residues. In case of lysines S-adenosyl-methionine (SAM) dependent methyl transferases catalyze the transfer of one, two or three methyl groups. Lysine methylation is reversible and lysine specific demethylases have been... 

Hu P, Zhang Y (2006) Catalytic mechanism and product specificity of the histone lysine methyl-transferase set7/9 An ab initio QM/MM-FE study with multiple initial structures. J Am Chem Soc... 

Rea S, Eisenhaber F, O Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T (2000) Regulation of chromatin structure by site-specific histone H3 methyl-transferases. Nature 406 593-599... 

Schafer DA, Schroer TA (1999) Actin-related proteins. Annu Rev Cell Dev Biol 15 341-363 Schurter BT, Koh SS, Chen D, Bunick GJ, Harp JM, Hanson BL, Henschen-Edman A, Mackay DR, Stallcup MR, Aswad DW (2001) Methylation of histone H3 by coactivator-associated arginine methyl-transferase 1. Biochemistry 40 5747—5756... 

A number of proteins such as histones, cytochrome c and certain flagellar proteins are found to contain methylated amino acids (19). Three different methylases have been characterized and all require S-adenosylmethionine (SAM) as the methyl donor (20-23). Protein methylase I (SAM-protein arginine methyl transferase) methylates the guanidine side chain of arginine residue protein methylase II (SAM-protein carboxyl methyltransferase) transfers methyl groups only to 8- and y-carboxyl groups in the peptide chain. Carboxyl groups in the a position cannot serve as acceptors. Protein methylase III (SAM-protein lysine... 

Zinc Clusters Class II Histone Lysine Methyl Transferases... 

Tuck, M. T., Farooqui, J. Z., Paik, W. K. (1985). Two histone Hl-specific protein-lysine N-methyl-transferases from Euglena gracilis Purification and characterization. J. Biol. Chem. 260, 7114-7121. 

Methylation. Protein methylation serves several purposes in eukaryotes. The methylation of altered aspartate residues by a specific type of methyltransferase promotes either the repair or the degradation of damaged proteins. Other methyl-transferases catalyze reactions that alter the cellular roles of certain proteins. For example, methylated lysine residues have been found in such disparate proteins as ribulose-2,3-bisphosphate carboxylase, calmodulin, histones, certain ribo-... 

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