Lung, gene expression studies vector delivery

Figure 4.2 (See color insert) Adeno-associated viral delivery of dual function reporter gene to the lungs of Balb/c mice. Mice were treated with two different AAV vectors encoding the same dual function reporter gene comprised of Flue and YFP (Brindle and Contag, Unpubhshed data). Animals were imaged for luciferase expression (a and b) and after the study fluorescence micrographs (c and d) were used to validate gene delivery to the lungs. Effective gene delivery is shown in b and d, whereas the absence of effective delivery is shown in a and b.

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