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Endosomal release, gene carriers

There are several steps in gene transfection such as the DNA complexation, cellular uptake of the complexes, release of DNA or complexes from endosomes, release of DNA from the carriers, and transfer into the nucleus (Zabner et al. 1995). Among them, an inefficient release of DNA in the polymer/DNA complexes from endosomes into the cytoplasm is one of the primary causes of poor transfection efficiency as the intracellular barrier. Therefore, pH-sensitive chitosan carriers have been tried to overcome the intracellular barrier. [Pg.383]

See other pages where Endosomal release, gene carriers is mentioned: [Pg.229]    [Pg.241]    [Pg.284]    [Pg.296]    [Pg.296]    [Pg.124]    [Pg.520]    [Pg.599]    [Pg.236]    [Pg.240]    [Pg.253]    [Pg.576]    [Pg.242]    [Pg.354]    [Pg.236]    [Pg.213]    [Pg.217]    [Pg.528]    [Pg.117]    [Pg.135]    [Pg.208]    [Pg.439]    [Pg.118]    [Pg.517]    [Pg.194]    [Pg.207]    [Pg.65]    [Pg.383]    [Pg.124]    [Pg.1148]   
See also in sourсe #XX -- [ Pg.296 ]



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Endosomal release

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