Apoptosis gemcitabine

Of course other methods of radiation enhancement may take place with reoxygenation of hypoxic tumor cells that may be increased with the use of chemotherapies like paclitaxel or gemcitabine (41,42), improved drug access to the tumor cells after radiotherapy, or a lowering of the threshold for radiation-induced apoptosis as has been described with the use of gemcitabine (43). 

Huang P, Plunkett W. Fludarabine and gemcitabine induced apoptosis Incorporation of analogs into DNA is a critical event. Cancer Chemother Pharmacol 1995 36 181-188. 

Modrak, D.E., Cardillo, T.M., Newsome, G.A., Goldenberg, D.M., and Gold, D.V. Synergistic interaction between sphingomyelin and gemcitabine potentiates ceramide-mediated apoptosis in pancreatic cancer. Cancer Res, 64, 2004, 8405-8410. 

In the case of gemcitabine, the efficacy of a combined treatment in terms of apoptosis induction has been analyzed in more detail using HT29 colon cancer cells, UMSCC-6 head and neck cancer cells, and A549 lung cancer cells. A key feature was that all cell systems... 

Zisman, A., Ng, C.R., Rantuck, A.J., Bonavida, B., and Belldegrun, A.S. (2001). Actinomycin D and gemcitabine synergistically sensitize androgen-independent prostate cancer cells to Apo2L/TRAIL-mediated apoptosis. J. Immunother. 24, 459-471. 

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