Gemcitabine hydrochloride

Fig. 3. NMR of gemcitabine. Lower spectrum shows a solution of gemcitabine hydrochloride at pH 3.2. For comparison, the upper spectrum was obtained in the presence of sodium hydroxide at pH 8.4. Each spectrum required about 1 min at 376 MHz (9.4 T) (data acquired in collaboration with Dr. Peter Peschke, DKFZ, Heidelberg, Germany).

Table 4 HPLC Results Obtained on Thermally Stressed Solutions of Gemcitabine Hydrochloride...

Figure 6 HPLC chromatogram obtained on a solution of gemcitabine hydrochloride in pH 3.2 acetate buffer stressed at 70°C for 2 days.

Jansen PJ, Akers MJ, Amos RM, Baertschi SW, Cooke GG, Dorman DE, Kemp CAJ, Maple SR, McCune KA. The degradation of the anti-tumor agent gemcitabine hydrochloride in an acidic aqueous solution at pH 3.2 and identification of degradation products. J Pharm Sci 2000 89(7) 885-891. 

GEMCITABINE HYDROCHLORIDE (Gemzar lyophilized powder for injection 200 mg)... 

Trissel LA, Zhang Y (2005) Physical and chemical stability of palonosetron hydrochloride with fluorouracd and with gemcitabine hydrochloride during simulated Y-site administration. Int J Pharm Compd 9 320-322. 

---