Gemcitabine Cisplatin

Cisplatin-gemcitabine renal, neuropathy, weakness, hypersensitivity, anemia Febrile neutropenia, infection, thrombocytopenia, nausea, vomiting, High (day 1) Mild (days 8 and 1 5)... 

Newer platinum-based combinations have proven effective in Phase-II studies of patients with advanced disease. Carboplatin/paclitaxel (response rate 23%) and cisplatin/gemcitabine (response rate 24%) have figured prominently [142] [143], The carboplatin/paclitaxel combination appears remarkably active in the induction setting, as Dang et al. reported response rates of 95% [144], and also when given weekly with concurrent radiotherapy... 

Carboplatin in combination with paclitaxel has shown activity in recently reported phase II trials. Vaughn et al. [163] at the University of Pennsylvania reported a 50% response rate in previously untreated patients with advanced disease, while Droz et al. [164] observed responses in 14 of 38 patients (2 CRs). Randomized comparisons of this combination with M-VAC are expected. Kaufman et al. [165] reported promising results with the cisplatin/gemcitabine combination at ASCO in 1998 a 66% response rate (13 CRs) was observed in their Phase-II study of 47 patients. 

Lung non-small cell) MIC mitomycin + ifosfamide cisplatin MVPi micomycin + vinblastine + cisplatin Cisplatin + gemcitabine vinorelbine... 

Kuenen BC, Rosen L, Smit EF, Parson MR, Levi M, et al. 2002. Dosefinding and pharmacokinetics study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J. Clin. Oncol. 20 1657-67... 

Frasci G, Panza N, Cornelia P, et al. Cisplatin, gemcitabine, and paclitaxel in locally advanced or metastatic non-small-cell lung cancer A phase 1-11 study. J Clin Oncol 1999 17 2316-2325. 

European study in which patients with advanced NSCLC were randomized to cisplatin-gemcitabine chemotherapy alone, cisplatin-gemcitabine plus bevaci-zumab 7.5 mg/kg, or cisplatin-gemcitabine plus bevacizumab 15 mg/kg were greeted with interest, as both doses of bevacizumab were associated with prolonged progression-free survival [153]. 

Joyce, a psychologist. Ovarian cancer, stage 3, diagnosed in 2004 at age fifty-eight. (Treatment surgery, hysterectomy, splenectomy, and colon resection. Chemo carboplatin, paclitaxel, cisplatin, gemcitabine, topotecan, doxorubicin.)... 

Cisplatin, gemcitabine Magnetic nanoparticles—PLC Antineoplastic agent... 

Umanzor J, Aguiluz M, Pineda C. Concurrent cisplatin/gemcitabine chemotherapy along with radiotherapy in locally advanced cervical carcinoma A phase II trail. Gynaecol Oncol 2006 100 70-5. 

Combination studies of olaparib are being explored clinically with a number of agents, including irinotecan, dacarbazine, carboplatin, gemcitabine, doxorubicin, cisplatin, and topotecan. 

Four to six cycles of doublet chemotherapy with cisplatin or carboplatin plus docetaxel, gemcitabine, paclitaxel, or vinorelbine are recommended as first-line chemotherapy for patients with unresectable stage III or IV NSCLC. No combination was found to be superior tolerance of expected toxicities may contribute to the decision. 

Etoposide/cisplatin Vinorelbine/gemcitabine Paclitaxel/gemcitabine Gemcita bi ne/ docetaxel Paclitaxel/vinorelbine... 

Giaccone, G. et al., Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer a phase 111 trial-lNTACT, /. Clin. Oncol., 22, 777-784, 2004. 

Vokes EE, Leopold KA, Herndon JE, et al. CALGB Study 9431 Arandomized phase study of cisplatin with gemcitabine or paclitaxel or vinorelbine as induction chemotherapy and concomitant chemoradiotherapy for unresectable stage III non-small cell lung cancer. Lung Cancer 2000 29(Sl) 49(Abstract 158). 

Goss G, Lochrin C, Perry G, et al. A phase I study of gemcitabine and Cisplatin with concurrent curative irradiation in Stage III Non-small cell lung cancer (NSCLC). Pro Am Soc Clin Oncol 1999 18 abstract 1986. 

Fossella FV, Zinner RG, Komaki R, et al. Gemcitabine with concurrent chest radiation followed by consolidation chemotherapy with gemcitabine plus cisplatin A phase I trial for patients with stage III non-small cell lung cancer. Lung Cancer 2000 29(Suppl 1) 111 (abstract 368). 

Benasso M, Merlano M, Corvo R, Sanguineti G, Numico G, Di Costanzo G, Ricci I, Rosso R. Alternat-ing/concomitant gemcitabine (GEM), cisplatin (CDDP) and radiotherapy (RT) in advanced squamous cell carcinoma of the head and neck (SCC-HN). Proc ASCO 1998 17 403a (abstract 1552). 

S af ar AM, Altamiro PS, Recht A, et al. Phase I trial of gemcitabine, cisplatin and external beam radiation therapy for pancreatic cancer. Proc Am Soc Clin Oncol 1999 18 227a. 

Fuloria JF, Parikh PM, Prabhakaran PS, et al. A multicenter, phase II trial of gemcitabine and cisplatin in unresectable hepatocellular carcinoma. Proc Am Soc Clin Oncol 2000 19 29. 

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