Plasma gastrin

Gastrin Plasma Diagnosis of Zollinger-Elllson syndrome... 

Saccomani G, Crago S, Mihas A, Dailey DW, Sachs G (1978) Tissue and cell localization of hog gastrin plasma membrane by antibody techniques. Acta Physiol Scand Suppl 1978 293-305... 

Gastrin inhibition. Hydrogenated oil, administered to adult rats, produced a significant reduction in antral and plasma gastrin concentrations . Gastrointestinal effect. Oil, administered to rats, induced the secretion of surfactantlike particles in the small intestine ". Genotoxic activity. Coconut oil acid diethanolamine condensate with or without S9 activation enzyme, in cell culture, pro-... 

CN171 Frank-Peterside, N. The effect of different dietary fats on gastrin levels in the pyloric antrum and plasma of weaner and adult Wistar rats. Afr J Med Med Sci 2000 29(2) 135-139. 

A counterpart of evidence that CCK agonists are anxiogenic is to answer the question of whether the CCK system is functionally implicated in non-provoked symptoms of panic or anxiety. It is conceivable that endogenous variations of central and/or peripheral CCK activity may be a neurochemical concomitant of anxiety. It is interesting to mention that serum concentrations of gastrin, a CCK-B agonist, fluctuate in correlation with self-reported tension, conflict, and anxiety in psychiatrically healthy men (M. Feldman et al. 1992). Plasma CCK levels were markedly elevated in sportsmen before a competitive marathon run, as compared with CCK levels under control conditions (Phillip et al. 1992). Plasma concentrations of adrenocorticotropic hormone (ACTH), cortisol, and noradrenaline were also elevated and increased extensively after the running performance. However, CCK levels re-... 

Redrawn from data in Lanzon-Miller S et al Twenty-four-hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine or omeprazole. Aliment Pharmacol Ther 1987 1 239.)... 

Figure 1. Conscious cat with gastric fistula. Effect of (R)a-methylhistamine (MHA, pmol/kg i.v.) on acid secretion and plasma gastrin levels stimulated by 2-deoxy-D-glucose (100 mg/kg i.v.) (Co). On the ordinate percent responses in comparison with maximum responses considered arbitrarily as 100. Mean values SEM from 5 cats. P <0.05 and 73<0 01 vs control values.

Katz LB, Schoof RA, Shriver DA (1987) Use of a five-day test to predict the long-term effects of gastric antisecretory agents on serum gastrin in rats. J Pharmacol Meth 18 275-282 Larsson H, Carlsson E, Mattsson H et al. (1986) Plasma gastrin and gastric enterochromaffin-like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 90 391-399... 

Williams MP, Blanshard C, MiUson C, Sercombe J, Pounder RE. A placebo-controlled study to assess the effects of 7-day dosing with 10, 20 and 40 mg rabeprazole on 24-h intragastric acidity and plasma gastrin in healthy male subjects. Aliment Pharmacol Ther 2000 14(6) 691-9. 

Although delays of a specimen in transit from a patient in a hospital to the laboratory are usually short, the time elapsing from the separation of serum and cells until analysis may be considerable. The specimen must be properly treated both during its transport to the laboratory and from the time the serum has been separated until it is analyzed. For some tests, specimens must be kept at 4 C from the time the blood is drawn mitil the specimens are analyzed, or until the serum or plasma is separated from the cells. Examples are specimens for ammonia and blood gas determinations, such as PCO2, PO2, and blood pH (see Chapter 27). Transfer of these specimens to the laboratory must be done by placing the specimen container in ice water. Specimens for acid phosphatase, lactate and pyruvate, and certain hormone tests (e.g., gastrin and renin activity) should be treated the same way. A notable decrease in pyruvate and increase in lactate concentration occurs within a few minutes at ambient temperature (see Chapter 25). 

Amphetamines increase the concentration of free fatty adds. Morphine increases the activity of amylase and lipase, alanine and aspartate aminotransferases, ALP and the serum bilirubin concentration. The concentrations of gastrin, TSH, and prolactin are also increased. In contrast the concentrations of insulin, norepinephrine, pancreatic polypeptide, and neurotensin are decreased. Heroin increases the plasma concentrations of cholesterol, thyroxine, and potassium. PCO2 is increased but PO2 is decreased. The plasma albumin concentration is also decreased. Cannabis increases the plasma concentrations of sodium, potassium, urea, chloride, and insulin but decreases those of creatinine, glucose, and urate. 

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