Gastric cancer lycopene

Data concerning gastric cancer are scarce. The prospective Netherlands Cohort Study found no correlation between lutein dietary intake and gastric cancer risk, whereas findings from the Physicians Health Study and the ATBC study reported no effect of P-carotene on gastric cancer incidence. Two case-control studies and three intervention trials (ATBC, CARET, and the Physicians Health Study ) showed no association of P-carotene, lycopene, lutein, zeaxanthin, and P-cryptoxanthin. 

Luo et al. [18] Gastric cancer Enhances antioxidant enzyme activities and immunity function Lycopene increased blood IL-2, IL-4, IL-10, TNF-a levels and reduced the IL-6 level and enhanced blood IgA, IgG, and IgM levels in gastric cancer rats Decreased MDA and increased blood and gastric antioxidant parameters (SOD, CAT, and GSH-Px)... 

Luo C, Wu XG (2011) Lycopene enhances antioxidant enzyme activities and immunity function in JV-methyl-N -nitro-N-nitrosoguanidine-induced gastric cancer rats. Int J Mol Sci... 

Yang, T., Yang, X., Wang, X., Wang, Y., Song, Z. (2013). The role of tomato products and lycopene in the prevention of gastric cancer A meta-analysis of epidemiologic studies. Medical Hypotheses, 80, 383-388. 

Carotenoids and urino-digestive cancers — On the whole, findings from epidemiological studies did not demonstrate a protective role of carotenoids against colorectal, gastric, and bladder cancers. Indeed, most prospective and case-control studies of colorectal cancer showed no association with dietary intake or plasma level of most carotenoids. - Only lycopene and lutein were shown to be protective against colorectal cancer. Otherwise, findings from the ATBC study s showed no effect of P-carotene supplementation on colorectal cancer. 

Velmurugan, B., Bhuvaneswari, V., Burra, U.K., and Nagini, S. 2002. Prevention of N-methyl-N -nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene. Eur J Cancer Prev 11 19-26. 

Velmurugan B, Mani A, Nagini S (2005) Combination of S-allylcysteine and lycopene Induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. Eur J Cancer Prev 14 387-393... 

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