Gastric atrophic gastritis

Alterations in other gastric secretions, such as pepsinogens and blood group substances also take place in chronic atrophic gastritis. The secretion of pepsinogen I has been used as an indicator of intestinal metaplasia and gastric cancer (21, 22). 

The nitrite results from reduction of nitrate by bacteria abnormally present in the gastric mucosa and the gastric cavity. The bacteria grow situ because the pH is elevated as a result of loss of HCl secretion secondary to the loss of parietal cells and their replacement by intestinal-type epithelium. Parietal cells are lost as a result of chronic atrophic gastritis. What... 

Prolonged hypergastrinemia leading to the development of colonic polyps and potentially adenocarcinoma in rats was a concern that has proven to be unfounded with long-term use in humans.19 The FDA has stated that there is insufficient evidence linking PPI use to atrophic gastritis, intestinal metaplasia, or gastric cancer.20... 

Gastritis Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole and esomeprazole. 

Among patients infected with H pylori, long-term acid suppression leads to increased chronic inflammation in the gastric body and decreased inflammation in the antrum. Concerns have been raised that increased gastric inflammation may accelerate gastric gland atrophy (atrophic gastritis) and intestinal metaplasia—known risk factors for... 

Negrini, R., Savio, A., Poiesi, C., Appelmelk, B.J., Buffoli, F., Paterlini, A., Cesari, P., Graffeo, M., Vaira, D., Franzin, G. Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology 111 (1996) 655-665. 

Atrophic gastritis will cause decreased secretion of gastric acid before there is any impairment of intrinsic factor secretion. This means that the absorption of crystalline vitamin B12, as used in the Schilling test, is normal but the absorption of protein-bound vitamin B12 from foods will be impaired (Section 10.7.1), and the Schilling test will give a false-negative result. 

The mucoprotein fraction concentration in gastric juice correlated with HCl and pepsin (G27, G52, G53) secretion, increased on vagal stimulation (G25, G27-G29, G35, G48, G52), and was absent or appeared in traces in juices of patients with pernicious anemia (Gll, G38) and those with advanced atrophic gastritis (Gll, G22, G28). 

H13. Hennes, A. R., Sevelius, H., Lewell) , T., Joel, W., Woods, A. H., and Wolf, S., Atrophic gastritis in dogs. Production by intradermal injection of gastric juice in Freund s adjuvant. Arch. Pathol. 73, 281-287 (1962). 

Ul. Uchino, H., Schwartz, G. H., and Glass, G. B. J., Paper electrophoretic analysis of B] 2 hiding in the gastric juice of normals, pernicious anemia patients and subjects with histamine-fast anacidity and atrophic gastritis. Clin. Chim. Acta 9, 461-473 (1964). 

Yamakawa (Yl) studied 150 juices by free boundary and paper electrophoresis in veronal buflFer of pH 8.6, phosphate buffer of pH 7.6, borate buffer of pH 5.8, and acetate buffer of pH 4.5. The normal electrophoretic pattern consisted of four to seven peaks, of which four were considered to be main components. The best resolution was obtained with the first three buffers. In gastric ulcer, the slowest component, B4, was increased whereas, in atrophic gastritis and gastric cancer, components B3 and B4 were high and additional subcomponents were noted. 

In an extension of these studies, Wada et al. (Wl) reported the incidence of positive precipitation reactions for serum proteins by the Ouchterlony technique to be 77.0% in gastric cancer (26 cases) and 64.5% in chronic gastritis (31 cases). However, this held true in only 15-20% of peptic ulcer cases. In atrophic gastritis, 6-8 precipitation lines were obtained with antisera to human serum and these included intensive lines of albumin and yglobulin and also faint lines of oro-somucoid, a2-globulin, ceruloplasmin, transferrin, and (3-globulin. 

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