Gastritis, severe atrophic

Patients with severe atrophic gastritis may have impaired absorption of vitamin B12 and a reduced serum level of the vitamin, but this is not accompanied by either megaloblastic anemia or neuropathy. Parietal-cell antibodies have been found in 33% of patients with gastritis, none of these patients having pernicious anemia (12, V4). Intrinsic factor antibodies were not found, and this was not surprising since it is rare to find antibodies to intrinsic factor in the absence of pernicious anemia. Patients with superficial gastritis usually have normal vitamin B12 absorption and normal serum levels of the vitamin. 

Moderate nausea, diarrhea, or abdominal pain can occur in patients taking omeprazole (13). There is an increased incidence of the severe interstitial and atrophic forms of gastritis, associated with moderate hypergastrinemia and hjrperplasia of the argyrophil cells (1). This is not necessarily an adverse effect it could represent the natural history of chronic gastritis associated with peptic ulcer disease. 

Krasinski, S.D., Russell, R.M., Samlolf, I.M., Jacob, R.A., Dallal, G.E., McGandy, R.B., and Hartz, S.C., 1986. Fundic atrophic gastritis in an elderly population effect on hemoglobin and several serum nutritional indicators. Journal of the American Geriatrics Society. 34 800-806. 

---