Gangliosides mimicry

Pathogenic Anti-Ganglioside Antibodies and C. jejuni Ganglioside Mimicry... 

The observation that GBS-associated C. jejuni isolates exhibit ganglioside mimicry prompted a number of studies that showed the reactivity of serum antibodies in GBS patients, against not only C. jejuni LOS (Yuki et al., 1993 Schwerer et al., 1995 Neisser et al., 1997, 2000), but particularly against the core OS mimicking ganglio-sides (Prendergast et al., 1999). Cross-reactive anti-GMi and -GDia antibodies were... 

Guerry, P., Szymanski, C.M., Prendergast, M.M., Hickey, T.E., Ewing, C.P., Pattarini, D.L., Moran A.P. Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro. Infect Immun 70 (2002) 787-793. 

Yuki, N. Ganglioside mimicry and peripheral nerve disease. Muscle Nerve 35 (2007) 691-711. 

Prendergast, M.M., Lastovica, A.J., Moran, A.P. Lipopolysaccharides from Campylobacter jejuni 0 41 strains associated with Guillain-Barre syndrome exhibit mimicry of GM1 ganglioside. Infect Immun 66 (1998) 3649-3655. 

Yuki, N., Susuki, K.,Koga, M., Nishimoto, Y., Odaka, M., Hirata, K., Taguchi, K., Miyatake, T., Furukawa, K., Kobata, T., Yamada, M. Carbohydrate mimicry between human ganglioside GMI and Campylobacter jejuni UpooUgosaccharide causes GuiUain-Barre syndrome. ProcNatl AcadSci USA 101 (2004) 11404-11409. 

Yuki N, Susuki K, Koga M, Nishimoto Y, Odaka M, Hirata K, Taguchi K, Miyatake T, Furukawa K, Kobata T, Yamada M (2004) Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni UpooUgosaccharide causes GuiUain-Barre syndrome. Proc Natl Acad Sci US A 101 11404-11409... 

Keywords Acute flaccid paralysis Anti-ganglioside antibodies Campylobacter jejuni Experimental allergic/autoimmune neurids (BAN) Gangliosides Immune neuropathies Molecular mimicry T-cells... 

Yuki N, Taki T, Takahashi M, Saito K, Yoshino H, Tai T, Handa S, Miyatake T (1994) Molecular mimicry between GQ ganglioside and lipopolysaccharides of Campylobacter jejuni isolated from patients with Fisher s syndrome. Ann Neurol 36 791—793. 

Carbohydrate mimicry between human ganglioside GMl and Campylobacter jejuni lipooligosacchaiide causes Guillain-Bane syndrome. Proc Natl Acad Sci USA 101 11404—11409. 

Nachamkin I, Ung H, Moran AP, Yoo D, Prendergast MM, Nicholson MA, Sheikh K, Ho T, Asbury AK, McKhann GM, Griffin JW (1999) Ganglioside GMl mimicry in Campylobacter strains from sporadic infections in the United States. J Infect Dis 179 1183-1189. 

Yu RK, Usuki S, and Ariga T (2006) Ganglioside molecular mimicry and its pafliologi-cal roles in Guillain-Barre syndrome and related diseases. Infect Immun 74 6517—6527... 

The structure of the core ohgosaccharides of Campylobacter jejuni 02 LPS was found to contain 3-deoxy-D-m nno-octulosonic acid (Kdo), L-glycero-D-manno-heptose (LD-Hep), D-Gal, D-Glc and phosphoethanolamine based on H, and P NMR. Molecular mimicry in C. jejuni LPS has been implicated in the pathogenesis of Guillain-Barre syndrome by inducing antibodies to human gangliosides. 

Finally an intriguing aspect of H. influenzae infections warrants mention. These bacteria express a lipopolysaccharide whose exposed surface is decorated with phosphorylcholine. As described in Chapter 1, phosphorylcholine is a building block of phosphatidylcholine, a major membrane lipid of eukaryotic cells. However, most bacteria lack phosphatidylcholine and thus H. influenzae has to rely on host cell lipids to obtain phosphorylcholine. The transfer of phosphorylcholine from the host to the bacterial cell surface is an adaptative process that allows the pathogen to mimic characteristics of host cells and to become more resistant to host immune responses. Another astonishing case of "lipid mimicry" has been reported for H. influenzae. A particular strain of nontypable H. influenzae seemed to express a ganglioside GMl-like structure that has been suspected as a generator of anti-GMl antibodies responsible for an axonal Guillain-Barre syndrome. ... 

Yuki, N., Handa, S., Taki, T., Kasama, T., Takahashi, M., Saito, K., and Miyatake, T., 1992, Cross-reactive antigen between nervous tissue and a bacterium elicits Guillain-Barre syndrome. Molecular mimicry between ganglioside GMl and liposaccharide from Penner s serotype 19 of Campylobacter jejuni, Biomed. Res. 13 451-453. 

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