Furazolidone dosing

Additional studies have demonstrated that incurred residues of furaltadone and furazolidone in tissues of veal calves are rapidly decreased postmortem. Two h after slaughtering, only traces of the parent drugs could be determined in muscle and kidney tissues, whereas residues of the parent drugs could no longer be detected in the liver (39). In chicken liver, furazolidone is also rapidly degraded postmortem more than 95% of a furazolidone dose spiked to a liver tissue sample kept at 32 C could be degraded in 15 min (40). 

O All symptomatic adults and children over the age of 8 years should be treated with metronidazole 250 mg three times daily for 7 days, or tinidazole 2 gas a single dose, or nitazoxanide 500 mg twice daily for 3 days.3 The pediatric dose of metronidazole is 15 mg/kg per day three times daily far 7 days. Alternative drugs include furazolidone 100 mg four times daily or paromomycin 25 to 30 mg/kg per day in divided doses daily for 7 days. Paromomycin may be used in pregnancy instead of metronidazole. Pediatric patients can also be treated with suspensions of either furazolidone 8 mg/kg per day in four divided doses far 7 days, or nitazoxanide (Alina) 100 to 200 mg every 12 hours for 3 days. 

Antibiotics shorten the duration of diarrhea, decrease the volume of fluid lost, and shorten the duration of the carrier state (see Table 39-3). A single dose of oral doxycycline is the preferred agent. In children younger than 7 years of age, trimethoprim-sulfamethoxazole, erythromycin, and furazolidone can be used. In areas of high tetracycline resistance, fluoroquinolones are effective. 

Fixed dose combination of loperamide hydrochloride with furazolidone. 

The nitrofurans are primarily known for their antibacterial activity however, a few compounds have been found to possess marked activity against filariasis and schistosomiasis. In experimental filariasis nitrofurazone (1), nitrofurantoin (2), nifur-timox (3), furazolidone (4) and furapyrimidone (5) have been shown to kill both the microfilariae and adult worms of L. carinii at parenteral doses ranging from 15-150 mg/kg for 5 days [4-9]. Of these, nifurtimox (3), furazolidone (4) and furapyrimidone (5) have shown good activity against human filariasis. 

Oorsprong, M.B.M. Kuiper, H.A. Toxicology In Vitro, in press). This could be demonstrated by using buthionine-S-sulfoximine, a specific inhibitor of GSH-synthesis, but so by using cultures containing S-labeled GSH, achieved by preincubation with S-methionine. In the latter case, there was a dose-related, increased loss of radiolabeled GSH, again in the absence of an effect on absolute GSH-levels (Figure 2). This effect may offer an explanation for the increased GSH-levels observed in livers from salmons and chars treated with furazolidone (72). 

Furazolidone, on the other hand, is excreted in the urine at a very low rate. The amount of nitrofurans found in the bloodstream or in the urine and faeces varies in accordance with the properties of each compound. The administered dose of nitrofurans cannot be totally accounted for by recovery studies. It must be assumed, therefore, that certain body tissues are capable... 

All test compounds are effective against systemic infection with Sal. typhosa. Nitrofurazone, furazolidone, and furaltadone are also effective against infection with Staph, aureus. In 1962 the activity of panfuran in vivo was determined against infections with Strep, pyogenes. Mice were inoculated intraperitoneally with a dose 1,000 times higher than the MLD of bacteria. Thereafter, panfuran and similar compounds were administered subcutaneously at 3, 24, 48, and 72 hours after inoculation. The results prove that panfuran is effective against Strep, pyogenes infections. 

Fakheri H, Merat S, Hosseini C, Malekzadeh R. Low-dose furazolidone in triple and quadruple regimens for Helicobacter pylori eradication. Aliment Pharmacol Ther (2004) 19, 89-93. 

A depressed woman taking daily doses of conjugated oestrogens 1.25 mg and amitriptyline 75 mg, was also given furazolidone 300 mg daily and diphenoxylate with atropine sulfate. Two days later she began to experi-enee blurred vision, profuse perspiration followed by alternate chills and hot flushes, restlessness, motor activity, persecutory delusions, auditory hallueinations and visual illusions. The symptoms cleared within a day of stopping the furazolidone. The reasons are not understood but the authors point out that furazolidone has MAO-inhibitory properties and that the symptoms were similar to those seen when the tricyclic antidepressants and MAOIs interaet. However the MAO-inhibitory activity of furazolidone normally develops over several days. Whether the concurrent use of atropine and amitriptyline (both of which have antimuscarinic activity)... 

Giardiasis - Several recent publications have reported the efficacy of metronidazole in the treatment of Giydla lamblia infections. A daily dose of 20 mg/kg for 5-7 days cured dyf> of W, children.°3 An increase in the daily dose to 30 mg/kg for 7 days cured 27 of 30 children. Of 17 patients (3-3 years) followed for 1-2 months after a 5-day course of treatment (270-500 mg/day), l6 were cured of the infection. The drug was reported to-be well tolerated with few undesirable side effects.°5 jn children, furazolidone (XVIl), given for 4 or 5 days at 10 and 5 mg/kg/day respectively, produced cure rates of 75 to 87. °°... 

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