Fungicides reproductive toxicity

Larsson et al. (1976) conducted an acute reproductive toxicity study in pregnant Sprague-Dawley rats and NMRI mice using maneb and mancozeb. The fungicides were administered in two different experiments (preliminary and final) by gavage, dissolved in water. The preliminary experiment involved doses of maneb at 0, 340, 650, 1,200 mg/kg/day, or mancozeb at 0, 300, 580, or 1060 mg/kg/day on gestation day 9 or 13... 

Another section of the EPA, the Office of Prevention, Pesticides, and Toxic Substances (OPPT), has recently updated and harmonized its testing guidelines for evaluating the developmental and reproductive effects of pesticides and industrial chemicals to include an assessment of endocrine disrupting properties. These guidelines will be used in future testing of pesticides under both the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). 

SAFETY PROFILE Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by skin contact. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. A fungicide and algicide used as a wood preservative. When heated to decomposition it emits acrid smoke and Sn+ fumes. See also TIN COMPOUNDS. 

ACGIH TLV TWA 0.1 mg/m Not Classifiable as a Human Carcinogen SAFETY PROFILE Confirmed carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A fungicide. When heated to decomposition it emits very toxic fumes of Cr, NOx, and SOx. 

SAFETY PROFILE Moderately toxic by ingestion. Experimental reproductive effects. A fungicide. Violent, potentially explosive reaction with concentrated peroxyformic acid. Violent reaction when heated with aluminum. See also COPPER COMPOUNDS. 

Chronic exposure to maneb has been related to reproductive, embryotoxic teratogenic, and neurotoxic effects. Although the toxicity associated with maneb exposure is low, it has been shown that in combination with other toxicants such as metals, other fungicides and herbicides the effects of maneb may be more pronounced, leading to more severe deficits. 

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