Vaginal fungal infections

Fluconazole (4) (s the first member of a new generation of orally acti ve antifungal agents, highly effective in the treatment of dermal and vaginal infections [6, 7] S-Fluorocyrtosine (5) is also used to treat serious systemic fungal infections [5]... 

Administration of miconazole for a vulvovaginal fungal infection may cause irritation, sensitization, or vulvo-vaginal burning. Skin irritation may result in redness, itching, burning, or skin fissures. Other adverse reactions with miconazole include cramping, nausea, and headache Adverse reactions associated with topical use are usually not severe. 

Vaginal pH less than or equal to 4.5 pH should remain normal in cases of fungal infection, while an elevated pH suggests bacterial infection. 

Use primarily for treatment of patients with progressive and potentially fatal fungal infections. Do not use to treat noninvasive forms of fungal disease such as oral thrush, vaginal candidiasis, and esophageal candidiasis in patients with normal neutrophil counts. 

Altered taste, vaginal candidiasis, fungal infection, dizziness, tongue discoloration Serious Reactions... 

Antifungal agents are used in the treatment of topical and systemic fungal infection. They can be classified as systemic or topical antifungal agents and some are used both systemically as well as topically in the form of powder, ointment and vaginal tablets etc. They are classified as in table 9.7.1. 

It is used orally for intestinal candidiasis, topically for oral, vaginal and cutaneous candidiasis and hospital treatment of progressive and potentially fatal systemic fungal infections. It is the gold standard of antifungal therapy. Flucytosine has supraadditive action with amphotericin B if the fungi is sensitive to both. It is also potentiated by rifampicin and minocycline. 

It is indicated in mucosal candidiasis, systemic candidiasis, crypttococcosis, prophylaxis of fungal infections following cytotoxic chemotherapy or radiotherapy maintenance to prevent relapse of cryptococcal meningitis in patients with AIDS sporotrichosis, histoplasmosis and vaginal candidiasis. 

Echinacea has been used investigationally to enhance hematologic recovery following chemotherapy. It has also been used as an adjunct in the treatment of urinary tract and vaginal fungal infections. These indications require further research before they can be accepted in clinical practice. E purpurea is ineffective in treating recurrent genital herpes. 

This agent is used topically for fungal infection (e.g., vaginal and scrotal infections and athlete s foot). 

Miconazole (Monistat) Vaginal candidiasis, severe systemic fungal infections. Phlebitis, pruritus, nausea, fever, rash, vomiting (if intravenous). 

Fungi, such as Candida spp. (yeast), are normal flora of mouth, skin, intestine, and vagina. Candidiasis might be an opportunistic infection when the defense mechanisms are impaired. Antibiotics, oral contraceptives, and immunosuppressives may alter the body s defense mechanisms. Infections can be mild (vaginal yeast infection) or severe (systemic fungal infection). 

Terconazole is an anti-fungal agent used to treat vaginal fungal infections. The synthesis of terconazole starts with pre-synthesized compound 2 and then is followed by alkylation of the 1,2,4-triazole followed by ether formation. ... 

Despite negligible cerebrospinal fluid concentrations, itraconazole shows promise in the treatment of cryptococcal and coccidioidal meningitis. Additional uses for itraconazole include treatment of vaginal candidiasis, tinea versicolor, dermatophyte infections, and onychomycosis. Fungal naU infections account for most use of this drug in the outpatient setting. 

Vaginal discharge - indicative of a local fungal or bacterial infection and pelvic examination may be required. 

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