Functional group chemistry

In later sections of this chapter we shall concentrate on the stereochemistry of target molecules, although the functional group chemistry will, of course, remain the basis of all synthetic operations. In this section we shall analyze synthetic functional group chemistry in two ways ... 

The Lead-Off Reaction Addition of HBr to Alkenes Students usually attach great-importance to a text s lead-off reaction because it is the first reaction they see and is discussed in such detail. 1 use the addition of HBr to an alkene as the lead-off to illustrate general principles of organic chemistry for several reasons the reaction is relatively straightforward it involves a common but important functional group no prior knowledge of stereochemistry or kinetics in needed to understand it and, most important, it is a polar reaction. As such, 1 believe that electrophilic addition reactions represent a much more useful and realistic introduction to functional-group chemistry than a lead-off such as radical alkane chlorination. 

We have described new routes to useful preceramic organosilicon polymers and have demonstrated that their design is an exercise in functional group chemistry. Furthermore, we have shown that an organosilicon polymer which seemed quite unpromising as far as application is concerned could, through further chemistry, be incorporated into new polymers whose properties in terms of ceramic yield and elemental composition were quite acceptable for use as precursors for ceramic materials. It is obvious that the chemist can make a significant impact on this area of ceramics. However, it should be stressed that the useful applications of this chemistry can only be developed by close collaboration between the chemist and the ceramist. 

Main Group Chemistry W Henderson d- and f-Block Chemistry CJ Jones Structure and Bonding J Barrett Functional Group Chemistry J R Hanson Organotransition Metal Chemistry A F Hill Heterocyclic Chsrtnsixy M Sainsbury Quantum Mechanics for Chemists D O Hayward... 

Crown ethers and cryptands show much of the same functional group chemistry as simple ether- or amine-containing molecules. The remarkable reactivity of these macropolycyclic species is primarily derived not from the composition of functional groups but from their three-dimensional arrangement. The important property of strong cation complexation is determined by the topology of the cavity defined by the ether and amine groups in the molecular superstructure. 

The functional group chemistry of samples with unknown composition have been inferred from the spectral features of well-characterized reference compounds such as the ones shown in Figure 17.6 by comparing band height and shapes in a qualita-... 

The SFC separation of nonsteroidal anti-inflammatory drugs (NSAIDs) was investigated by Jagota and Stewart [6]. These compounds vary in chemical structure and functional group chemistry and provide a representative sample of acidic drugs to study. Using a 10-m x 50-fim ID... 

A range of normal functional-group chemistry may be carried out with perfluoroalkanoic acids, little modified by the perfluoroalkyl group [2, 25, 26]. Acid chlorides are readily obtained with thionyl chloride or phosphoms chlorides and may be converted to the fluorides using potassium fluoride or, where a volatile product is obtained, by exchange with benzoyl fluoride (see Chapter 3, Section IIB) anhydrides are produced by reaction of the acid with phosphorus pentoxide [27]. To illustrate some of the chemistry of perfluoroalkanoic acids, a selection of reactions is contained in Table 8.3. 

The aims of the first chapter of this book are to provide the foundations for functional group chemistry. By the end of this chapter you should be able to understand ... 

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